Extensive impact of non-antibiotic drugs on human gut bacteria,Nature

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Extensive impact of non-antibiotic drugs on human gut bacteria
Nature ( IF 50.5 ) Pub Date : 2018-03-01 , DOI: 10.1038/nature25979
Lisa Maier ₁ , Mihaela Pruteanu ₁ , Michael Kuhn ₂ , Georg Zeller ₂ , Anja Telzerow ₁ , Exene Erin Anderson ₁ , Ana Rita Brochado ₁ , Keith Conrad Fernandez ₁ , Hitomi Dose ₃ , Hirotada Mori ₃ , Kiran Raosaheb Patil ₂ , Peer Bork _{2,

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6} , Athanasios Typas _{1,

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Affiliation

A few commonly used non-antibiotic drugs have recently been associated with changes in gut microbiome composition, but the extent of this phenomenon is unknown. Here, we screened more than 1,000 marketed drugs against 40 representative gut bacterial strains, and found that 24% of the drugs with human targets, including members of all therapeutic classes, inhibited the growth of at least one strain in vitro. Particular classes, such as the chemically diverse antipsychotics, were overrepresented in this group. The effects of human-targeted drugs on gut bacteria are reflected on their antibiotic-like side effects in humans and are concordant with existing human cohort studies. Susceptibility to antibiotics and human-targeted drugs correlates across bacterial species, suggesting common resistance mechanisms, which we verified for some drugs. The potential risk of non-antibiotics promoting antibiotic resistance warrants further exploration. Our results provide a resource for future research on drug–microbiome interactions, opening new paths for side effect control and drug repurposing, and broadening our view of antibiotic resistance.

中文翻译：

非抗生素药物对人体肠道细菌的广泛影响

最近发现一些常用的非抗生素药物与肠道微生物组组成的变化有关，但这种现象的程度尚不清楚。在这里，我们针对 40 种代表性肠道细菌菌株筛选了 1,000 多种市售药物，发现 24% 的具有人类靶点的药物（包括所有治疗类别的成员）在体外抑制了至少一种菌株的生长。特定类别的药物，例如化学成分多样的抗精神病药物，在这一组中所占比例过高。人类靶向药物对肠道细菌的影响反映在它们对人类的类似抗生素的副作用上，并且与现有的人类队列研究一致。对抗生素和人类靶向药物的敏感性与不同细菌种类相关，这表明存在共同的耐药机制，我们对某些药物进行了验证。非抗生素促进抗生素耐药性的潜在风险值得进一步探索。我们的研究结果为未来药物与微生物组相互作用的研究提供了资源，为副作用控制和药物再利用开辟了新途径，并拓宽了我们对抗生素耐药性的看法。

更新日期：2018-03-01

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