Preparation of 2,4,5-Trisubstituted Oxazoles through Iodine-mediated Aerobic Oxidative Cyclization of Enaminones,Organic Letters

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Preparation of 2,4,5-Trisubstituted Oxazoles through Iodine-mediated Aerobic Oxidative Cyclization of Enaminones
Organic Letters ( IF 4.9 ) Pub Date : 2018-03-19 00:00:00 , DOI: 10.1021/acs.orglett.8b00376
Yunxiang Weng ₁ , Weiwei Lv ₁ , Jia Yu ₁ , Bailu Ge ₁ , Guolin Cheng ₁

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A novel approach to trisubstituted oxazoles has been developed that is based upon an iodine-mediated aerobic oxidative cyclization of enaminone derivatives. This transition-metal-free procedure was highly efficient and involved the removal of four hydrogen atoms under mild conditions.

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