As surrogates of polybrominated diphenyl ethers (PBDEs), new flame retardants (NFRs) include a series of chlorinated and brominated flame retardants. Though the NFRs are thought to induce similar thyroid hormone (TH) disrupting effects as PBDEs, few studies have focused on them. Given the increasing levels of NFRs in the environment, more in depth investigation of the potential TH disrupting effects of NFRs is warranted. This research involved a health survey to collect data and examine the associations between PBDEs, NFRs and TH. 174 school students lived near a petrochemical complex in South China participated in the survey, completing questionnaires and providing blood samples. Thirteen congeners of PBDEs, eight species of NFRs, TH and thyroid-stimulating hormone (TSH) were measured. The median levels of ΣPBDE (sum of thirteen congeners of PBDEs) and ΣNFR (sum of eight species of NFRs) for students were 140 and 240 ng g⁻¹ lipid, respectively. Nonmonotonic relationships were observed between quartile levels of PBDEs, NFRs and corresponding TH. In contrast to ΣPBDE that was positively associated with triidothyrine (T₃) level, ΣNFR was not statistically associated with TH. ΣPBDE + NFR (sum of thirteen congeners of PBDEs and eight species of NFRs) was significantly associated with T₃ level.

作为多溴联苯醚（PBDE）的替代物，新型阻燃剂（NFR）包括一系列氯化和溴化阻燃剂。尽管人们认为NFR与PBDEs具有相似的甲状腺激素（TH）破坏作用，但很少有研究针对它们。鉴于环境中NFR的水平在不断增加，因此有必要对NFR的潜在TH破坏作用进行更深入的研究。这项研究涉及健康调查，以收集数据并检查PBDE，NFR和TH之间的关联。居住在华南石化基地附近的174名在校学生参加了调查，完成了问卷调查并提供了血液样本。测量了十三种多溴二苯醚的同系物，八种NFR，TH和甲状腺刺激激素（TSH）。^-1脂质。在PBDEs，NFRs和相应的TH的四分位数水平之间观察到非单调关系。与与三碘甲状腺素（T ₃）水平呈正相关的ΣPBDE相反，ΣNFR与TH没有统计学相关性。ΣPBDE+ NFR（十三种PBDEs和八种NFRs的总和）与T ₃水平显着相关。