The fascia and the fascial space can help provide a better understanding of the body. An intervaginal space injection (ISI) provides unique advantages that require further investigation. An upper limb model including physiological conditions and the tumor process was chosen to determine the flow behavior of liquid metal after ISI. In normal rats, after the injection of liquid metal into the intervaginal space comprising tendons, vessels, and nerves, magnetic resonance imaging and an anatomy experiment indicated that the liquid metal wrapped around the fascial space and finally reached the fingertip downstream and the armpit upstream in addition to the neurovascular bundle without vessels or lymph nodes. Using environmental scanning electron microscopy (ESEM) images, we discovered that the liquid metal was wrapped around the fibers of the fascia and moved forward in microscale or nanoscale areas. These data confirmed a fascia-based pathway. In tumors, the liquid metal moved to the tumor capsule through the damaged spot, where cancer cells destroy the integrity of the fascia between the normal cells and cancer cells. The liquid metal partly wrapped around the tumor and separated the tumor from the surrounding normal muscle. The ESEM images showed that fibers of the fascia penetrated the tumor, thus forming a network through which the liquid metal penetrated the tumor. Our study illustrated the physiological and pathological flow behavior of liquid metal in the upper limb after ISI and demonstrated a nonvascular pathway in the fascia. ISI may be useful for clinical treatment in the fascial pathway.

中文翻译：

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液态金属在相连筋膜腔中的流动行为：在大鼠手腕和患有肿瘤的小鼠中进行阴道间隙注射

筋膜和筋膜空间可帮助您更好地了解身体。阴道间隙注射（ISI）具有独特的优势，需要进一步研究。选择包括生理状况和肿瘤过程的上肢模型来确定ISI后液态金属的流动行为。在正常大鼠中，将液态金属注射到包括肌腱，血管和神经的阴道间隙后，磁共振成像和解剖学实验表明，液态金属包裹在筋膜空间周围，并最终到达了指尖的下游和腋窝的上游。除无血管或淋巴结的神经血管束外。使用环境扫描电子显微镜（ESEM）图像，我们发现液态金属包裹在筋膜的纤维周围，并在微米级或纳米级区域中向前移动。这些数据证实了基于筋膜的途径。在肿瘤中，液态金属通过受损部位移至肿瘤囊中，癌细胞破坏了正常细胞和癌细胞之间筋膜的完整性。液态金属部分包裹在肿瘤周围，并使肿瘤与周围的正常肌肉分离。ESEM图像显示筋膜的纤维穿透了肿瘤，从而形成了网络，液态金属通过该网络穿透了肿瘤。我们的研究阐明了ISI后上肢中液态金属的生理和病理流动行为，并显示了筋膜中的非血管通路。ISI可能在筋膜通路中用于临床治疗。