Stable trait-like responding is well established for neurobehavioral performance measures across repeated exposures to total sleep deprivation and partial chronic sleep restriction. These observed phenotypes are task-dependent, suggesting that there are distinct cognitive profiles of responding with differential vulnerability to sleep loss within the same individual. Numerous factors have been investigated as potential markers of phenotypic vulnerability to the effects of sleep loss but none fully account for this phenomenon. Observed interindividual differences in performance during extended wakefulness may be driven by underlying deficits in the wake-promoting system resulting in greater performance instability due to failure to counteract increased homeostatic pressure. Further work would benefit from a systems approach to the study of interindividual vulnerability in which behavioral, neurobiological, and genetic data are integrated in a larger framework delineating the relationships between genes, proteins, neurobiology, and behavior.

对于反复暴露于完全睡眠剥夺和部分慢性睡眠受限的神经行为表现指标，已经建立起稳定的特质样反应。这些观察到的表型是任务相关的，这表明在同一个人中，对于睡眠丧失的不同易感性存在不同的认知特征。已经研究了许多因素作为表型易受睡眠丧失影响的潜在标志，但没有一个因素能完全解释这种现象。唤醒觉醒系统中潜在的缺陷可能会导致长时间觉醒期间个人之间的性能差异，这是由于无法抵消增加的稳态压力而导致更大的性能不稳定。