Persulfate-promoted oxidative C–N bond coupling of quinoxalinones and NH-sulfoximines†,Organic & Biomolecular Chemistry

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Persulfate-promoted oxidative C–N bond coupling of quinoxalinones and NH-sulfoximines†
Organic & Biomolecular Chemistry ( IF 2.9 ) Pub Date : 2018-03-19 00:00:00 , DOI: 10.1039/c8ob00375k
Ladawan Sumunnee _{1,

2,

3,

4,

5} , Chaleena Pimpasri _{1,

2,

3,

4,

5} , Medena Noikham _{1,

2,

3,

4,

5} , Sirilata Yotphan _{1,

2,

3,

4,

5}

Affiliation

The persulfate-meditated oxidative C–N bond coupling of the C–H bond of quinoxalinones and the N–H bond of NH-sulfoximines is reported. The reaction proceeds smoothly under transition metal-free conditions and provides good to excellent yields of sulfoximidoyl-functionalized quinoxalinone products under mild conditions. The optimized conditions were found to be suitable for a range of sulfoximine and quinoxalinone substrates. This reaction offers a new and convenient strategy to directly install the sulfoximine moiety into the C3 position of quinoxalinone.

中文翻译：

过硫酸盐促进的喹喔啉酮与NH-亚磺酰亚胺键的氧化C–N键偶联†

据报道，过硫酸盐对喹喔啉酮的C–H键和NH-磺胺嘧啶的N–H键的氧化C–N键进行了偶联。该反应在无过渡金属的条件下平稳进行，在温和的条件下，磺基亚砜基官能化的喹喔啉酮产品收率好至极好。发现优化的条件适用于一系列磺胺嘧啶和喹喔啉酮底物。该反应提供了一种新的和方便的策略，可以直接将亚砜亚胺部分安装到喹喔啉酮的C3位置。

更新日期：2018-03-19

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