Iron(iii) coordination properties of ladanein, a flavone lead with a broad-spectrum antiviral activity†,New Journal of Chemistry

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Iron(iii) coordination properties of ladanein, a flavone lead with a broad-spectrum antiviral activity†
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2018-03-19 00:00:00 , DOI: 10.1039/c7nj04867j
X. Martin-Benlloch _{1,

2,

3,

4,

5} , A. Novodomska _{1,

2,

3,

4,

5} , D. Jacquemin _{6,

7,

8,

9,

10} , E. Davioud-Charvet _{1,

2,

3,

4,

5} , M. Elhabiri _{1,

2,

3,

4,

5}

Affiliation

Ladanein, a 5,6,7-trihydroxylayted flavone was recently shown to display potent antiviral activities toward enveloped virus particles (e.g., hepatitis C virus, human immunodeficiency virus, vesicular stomatitis virus). Fe(III) coordination and pH were suggested to be critical for bioactivation steps triggering host cell entry inhibition. The Fe(III) complexation properties of ladanein and related analogues, such as negletein and salvigenin, were then studied in solution under quasi-physiological conditions using physico-chemical tools and provided important insights into their stability/reactivity in solution.

中文翻译：

拉丹宁（一种具有广谱抗病毒活性的黄酮铅）的铁（iii）配位特性†

Ladanein，一种5,6,7-三羟基黄酮酮，最近显示出对包膜病毒颗粒（例如丙型肝炎病毒，人类免疫缺陷病毒，水疱性口炎病毒）显示出有效的抗病毒活性。Fe（III）的配位和pH被认为对于触发宿主细胞进入抑制的生物激活步骤至关重要。然后在准生理条件下使用物理化学工具在溶液中研究了拉丹宁和相关类似物（如negletein和salvigenin）的Fe（III）络合特性，并为其在溶液中的稳定性/反应性提供了重要的见识。

更新日期：2018-03-19

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