Large BAX/BAK pores that form during apoptosis enable mitochondrial nucleoids to access the cytosol, potentially leading to inflammatory signaling via CGAS. Under physiological conditions, however, BAX/BAK-dependent caspase activation rapidly dismantles dying cells to prevent inflammatory responses. BAX and BAK operate at the interface between apoptotic signaling and innate immunity control.

中文翻译：

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先天免疫之门的BAX和BAK

在凋亡过程中形成的大BAX / BAK孔使线粒体核苷能够进入胞质溶胶，从而可能通过CGAS引起炎症信号传导。然而，在生理条件下，依赖BAX / BAK的半胱天冬酶激活会迅速拆除垂死的细胞，以防止炎症反应。BAX和BAK在细胞凋亡信号传导和先天免疫控制之间的接口上运行。