Motor and vocal tics have long been recognised as the core features of Tourette syndrome (TS). However, patients’ first-person accounts have consistently reported that these involuntary motor manifestations have specific sensory correlates. These sensory symptoms are often described as feelings of mounting inner tension (“premonitory urges”) and are transiently relieved by tic expression. Multimodal hypersensitivity to external stimuli, perceived as triggers and/or exacerbating factors for specific tic symptoms, is also commonly reported by patients with TS. This article focuses on the rapidly expanding literature on the clinical and neurobiological aspects of the premonitory urge and multimodal hypersensitivity in patients with TS, with particular attention to pathophysiological mechanisms and possible treatment implications. These findings suggest that TS is a neurobehavioural condition characterised by intrinsic perceptual abnormalities involving the insula and sensorimotor areas, in addition to basal ganglia dysfunction. Further research will clarify the role of sensory symptoms in TS, as well as the effects of external sensory input on underlying motor abnormalities.

运动和声音抽动早已被认为是Tourette综合征（TS）的核心特征。然而，患者的第一人称记录一直报告这些非自愿运动表现具有特定的感觉相关性。这些感官症状通常被描述为内在紧张感不断增强（“督促冲动”），并通过抽搐的表达暂时缓解。TS患者也普遍报道了对外部刺激的多峰型超敏反应，被认为是特定抽动症状的触发因素和/或加剧因素。本文着眼于有关TS患者的临床前冲动和多模式超敏反应的临床和神经生物学方面的快速发展文献，尤其是病理生理机制和可能的治疗意义。这些发现表明，TS是一种神经行为病，其特征是除了基底神经节功能障碍外，还存在与岛突和感觉运动区有关的内在知觉异常。进一步的研究将阐明感觉症状在TS中的作用，以及外部感觉输入对潜在运动异常的影响。