The covalent modification of polymeric particles has been a challenge due to their chemical inertness. Herein we describe a facile and neat method via thiol-ene reaction to immobilize cysteamine/cysteine onto allylmethacrylate-divinylbenzene (AMA-DVB) and ethylvinylbenzene-divinylbenzene (EVB-DVB). The introduced functionalities were verified by elementary analysis and scanning electron microscope coupled with energy dispersive spectroscopy. This modification enabled the further grafting of hyperbranched condensation polymers (HBCPs), which converted the particles into anion exchangers. The anion exchangers demonstrated good separation with carbonate/bicarbonate eluents and hydroxide eluents for suppressed anion exchange chromatography. In the case of a 3-layered anion exchanger, simultaneous separation of nine model anions was achieved by isocratic elution in 17 min with efficiencies up to 16,100 plates m⁻¹. High stability and dependable durability was exhibited in long-term tests.

聚合物颗粒的共价改性由于其化学惰性而一直是一个挑战。在这里，我们描述了一种通过硫醇-烯反应将半胱胺/半胱氨酸固定在甲基丙烯酸烯丙酯-二乙烯基苯（AMA-DVB）和乙基乙烯基苯-二乙烯基苯（EVB-DVB）上的简便方法。通过元素分析和扫描电子显微镜结合能量色散光谱法验证了引入的功能。这种改性使得能够进一步接枝超支化缩聚物（HBCP），从而将颗粒转化为阴离子交换剂。阴离子交换剂表现出与碳酸根/碳酸氢根洗脱液和氢氧化物洗脱液的良好分离性，可抑制阴离子交换色谱分离。如果是三层阴离子交换剂，^-1。长期测试显示出高稳定性和可靠的耐用性。