A new chiral sensor based on weak measurement to accurately measure the optical rotation (OR) has been developed for the estimation of a trace amount of chiral molecule. With the principle of optical weak measurement in frequency domain, the central wavelength shift of output spectra is quantitatively relative to the angle of preselected polarization. Hence, a chiral molecule (e.g., L-amino acid, or D-amino acid) can be enantioselectively determined by modifying the preselection angle with the OR, which will cause the rotation of a polarization plane. The concentration of the chiral sample, corresponding to its optical activity, is quantitatively analyzed with the central wavelength shift of output spectra, which can be collected in real time. Immune to the refractive index change, the proposed chiral sensor is valid in complicated measuring circumstance. The detections of Proline enantiomer concentration in different solvents were implemented. The results demonstrated that weak measurement acted as a reliable method to chiral recognition of Proline enantiomers in diverse circumstance with the merits of high precision and good robustness. In addition, this real-time monitoring approach plays a crucial part in asymmetric synthesis and biological systems.

为了估计痕量的手性分子，已经开发了一种新的基于弱测量的手性传感器，可以精确地测量旋光度（OR）。根据频域中光弱测量的原理，输出光谱的中心波长偏移相对于预选偏振角是定量的。因此，可以通过用OR修饰预选择角来对映选择性地确定手性分子（例如，L-氨基酸或D-氨基酸），这将引起偏振面的旋转。利用输出光谱的中心波长位移，可以定量分析手性样品的浓度（对应于其光学活性），该光谱可以实时收集。不受折射率变化的影响，所提出的手性传感器在复杂的测量环境中是有效的。实施了在不同溶剂中脯氨酸对映异构体浓度的检测。结果表明，弱测量是在多种情况下手性识别脯氨酸对映体的可靠方法，具有高精度和良好的鲁棒性。另外，这种实时监测方法在不对称合成和生物系统中起着至关重要的作用。