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Novel synthesis of aminoacetonitriles via the selective demethylation of quaternary ammonium salts
Tetrahedron Letters ( IF 1.5 ) Pub Date : 2018-03-16 , DOI: 10.1016/j.tetlet.2018.03.037
Evgeny M. Buev , Anastasia A. Smorodina , Maxim A. Stepanov , Vladimir S. Moshkin , Vyacheslav Y. Sosnovskikh

N-Methyl cyclic amines readily formed quaternary ammonium salts upon treatment with iodoacetonitrile in high yields (70–96%). The latter were selectively demethylated by heating in dimethylformamide to give aminoacetonitriles in moderate to good overall yields (36–69%).



中文翻译:

通过季铵盐选择性脱甲基合成氨基乙腈的新方法

用碘乙腈处理后,N-甲基环胺很容易形成季铵盐(70-96%)。后者通过在二甲基甲酰胺中加热选择性脱甲基,得到氨基乙腈,总收率中等至良好(36-69%)。

更新日期:2018-03-16
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