This study aimed to determine the effect of metabolic syndrome (MS) on the reproductive function in fertile (FM) and male partners of infertile couples (MPIC). We performed a cross-sectional study formatting two study groups: partners of pregnant women (n = 238; mean age 32.0) as FM and male partners of infertile couples (n = 2642; mean age 32.6) as MPIC. A standard semen analysis was performed and clinical, laboratory and lifestyle data were analysed. The adapted NCEP-ATPIII criteria were used to define MS. 12.2% of FM and 17.8% of MPIC had MS. In both groups, men with MS were older, they were centrally obese and had higher triglycerides, systolic and diastolic blood pressure and decreased HDL cholesterol values as compared to men without MS. However, glucose concentrations as well as fasting insulin levels were significantly higher only in the MPIC-MS⁺ group. MS was not associated with semen parameters. Testosterone levels were negatively correlated to MS in both groups. This negative association persisted within the BMI categories between MPIC-MS^- and MPIC-MS⁺ groups. LH was negatively correlated to MS but only in MPIC. FSH and oestradiol were not correlated to MS. Smoking and alcohol consumption were higher among men with MS. This study shows that except for testosterone, MS has no independent effect on major fertility parameters in different subgroups of men.

这项研究旨在确定代谢综合征（MS）对可育夫妇（FM）和不育夫妇男性伴侣（MPIC）生殖功能的影响。我们进行了一项横断面研究，该研究分为两个研究组：孕妇的伴侣（n = 238；平均年龄32.0）为FM，不育夫妇的男性伴侣（n = 2642；平均年龄32.6）为MPIC。进行标准的精液分析，并分析临床，实验室和生活方式数据。调整后的NCEP-ATPIII标准用于定义MS。MS的FM为12.2％，MPIC的为17.8％。在这两组中，与没有MS的男性相比，患有MS的男性年龄更大，中枢肥胖，甘油三酸酯，收缩压和舒张压更高，HDL胆固醇值降低。然而，⁺组。MS与精液参数无关。两组中睾丸激素水平与MS呈负相关。此负关联持续MPIC-MS之间的BMI类别内^-和MPIC-MS ⁺基团。LH与MS呈负相关，但仅与MPIC相关。FSH和雌二醇与MS无关。多发性硬化症患者吸烟和饮酒的比例较高。这项研究表明，除睾丸激素外，MS对男性不同亚组的主要生育参数没有独立影响。