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Development of molecular imprinted polymers based strategies for the determination of Dopamine
Sensors and Actuators B: Chemical ( IF 8.0 ) Pub Date : 2018-03-16 , DOI: 10.1016/j.snb.2018.03.076
Shabi Abbas Zaidi

Dopamine (DA) is a valuable neurotransmitter of enormous biological significance and it is widely distributed in the mammalian central nervous system (CNS). DA has been known to play a critical role in the functioning of central nervous system (CNS), renal, and hormonal systems. It has been discovered that the lack of DA is associated with many clinical conditions including debilitating ailment, Schizophrenia, and Parkinson's disease. Many reliable methods have been reported for the accurate determination of DA, however, interferences from co-existing molecules such as ascorbic acid (AA), and Uric acid (UA) are inevitable. To overcome it, molecular imprinted polymer (MIP) is considered one of the best strategy owing to its pre-determined selectivity for an imprinted template. A considerable amount of research has been done on MIP based approach for DA determination. Furthermore, various types of ways including the utilization of conducting monomers, graphene, carbon nanotubes (CNTs), gold nanoparticles (AuNPs), and so on have been incorporated to enhance the signal response. In this review, we have not included the vast literature available for dopamine, instead, we have summarized the recent developments of MIP based strategies for the determination of DA using articles encompassing 2010 to till now as well as outlined the current challenges and developmental needs of MIP strategies.



中文翻译:

基于分子印迹聚合物的多巴胺测定策略的发展

多巴胺(DA)是有价值的神经递质,具有巨大的生物学意义,并且广泛分布于哺乳动物的中枢神经系统(CNS)中。已知DA在中枢神经系统(CNS),肾和激素系统的功能中起关键作用。已经发现,DA的缺乏与许多临床状况有关,包括使人衰弱的疾病,精神分裂症和帕金森氏病。已经报道了许多可靠的方法来精确测定DA,但是,不可避免地会受到诸如抗坏血酸(AA)和尿酸(UA)等共存分子的干扰。为了克服它,分子印迹聚合物(MIP)由于其对印迹模板的预定选择性而被认为是最佳策略之一。已经对基于MIP的DA确定方法进行了大量研究。此外,已经纳入了各种类型的方式,包括利用导电单体,石墨烯,碳纳米管(CNT),金纳米粒子(AuNPs)等来增强信号响应。在这篇综述中,我们没有包括可用于多巴胺的大量文献,相反,我们总结了基于MIP的用于确定DA的策略的最新进展,使用了直至2010年的文章,并概述了当前多巴胺的挑战和发展需求MIP策略。

更新日期:2018-03-16
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