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Studies towards the Synthesis of the Antibiotic Tetrodecamycin
Synlett ( IF 1.7 ) Pub Date : 2018-03-16 , DOI: 10.1055/s-0037-1609303 Victor Lee , Jing He 1 , Jack Baldwin 1
Synlett ( IF 1.7 ) Pub Date : 2018-03-16 , DOI: 10.1055/s-0037-1609303 Victor Lee , Jing He 1 , Jack Baldwin 1
Affiliation
A study towards the natural product tetrodecamycin is reported. A modified Schlosser–Wittig reaction was utilized to prepare the precursor for the subsequent intramolecular Diels–Alder reaction, which delivered the trans -decalin ring of the natural product. The tetronic acid moiety of the molecule was prepared by a Dieckmann cyclization. The cyclization of the tetronic acid to the trans -decalin double bond to form a seven-membered ring was examined.
中文翻译:
抗生素四十二霉素的合成研究
报道了对天然产物四十二霉素的研究。改进的 Schlosser-Wittig 反应用于制备随后的分子内 Diels-Alder 反应的前体,该反应提供天然产物的反式十氢化萘环。分子的特电子酸部分通过 Dieckmann 环化反应制备。检查了特电子酸环化成反式十氢化萘双键以形成七元环。
更新日期:2018-03-16
中文翻译:
抗生素四十二霉素的合成研究
报道了对天然产物四十二霉素的研究。改进的 Schlosser-Wittig 反应用于制备随后的分子内 Diels-Alder 反应的前体,该反应提供天然产物的反式十氢化萘环。分子的特电子酸部分通过 Dieckmann 环化反应制备。检查了特电子酸环化成反式十氢化萘双键以形成七元环。