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Aerobic, Metal-Free, and Catalytic Dehydrogenative Coupling of Heterocycles: En Route to Hedgehog Signaling Pathway Inhibitors
Organic Letters ( IF 4.9 ) Pub Date : 2018-03-16 00:00:00 , DOI: 10.1021/acs.orglett.8b00521
Luis Bering 1, 2 , Felix M. Paulussen 2 , Andrey P. Antonchick 1, 2
Affiliation  

The nitrosonium ion-catalyzed dehydrogenative coupling of heteroarenes under mild reaction conditions is reported. The developed method utilizes ambient molecular oxygen as a terminal oxidant, and only water is produced as byproduct. Dehydrogenative coupling of heteroarenes translated into the rapid discovery of novel hedgehog signaling pathway inhibitors, emphasizing the importance of the developed methodology.

中文翻译:

杂环的有氧,无金属和催化脱氢偶联:传递给刺猬信号通路抑制剂的途中

报道了在温和的反应条件下杂芳烃的硝基离子催化的脱氢偶联。所开发的方法利用环境分子氧作为末端氧化剂,仅产生水作为副产物。杂芳烃的脱氢偶联转化为新型刺猬信号通路抑制剂的快速发现,强调了已开发方法的重要性。
更新日期:2018-03-16
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