The effect of NaOH and NaClO/NaBr modification on the structural and physicochemical properties of dextran,New Journal of Chemistry

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The effect of NaOH and NaClO/NaBr modification on the structural and physicochemical properties of dextran
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2018-03-16 00:00:00 , DOI: 10.1039/c7nj04341d
Shuang Chen _{1,

2,

3,

4} , Hao Wu _{1,

2,

3,

4} , Jing-han Hua _{1,

2,

3,

4} , Jing-wen Yang _{1,

2,

3,

4} , Hong-bin Zhang _{1,

2,

3,

4} , Xue-qin Hu _{1,

2,

3,

4}

Affiliation

Dextran is a polysaccharide with a high medicinal value. Thus, the chemical modifications of dextran, and the structural and physicochemical properties of its derivatives should be given focus. Dextran (M_w 5000 Da to 7500 Da) can complex with iron. In this study, dextran (M_w 5400 Da) was modified at different pH levels (8–14) by using NaOH and NaClO/NaBr. The carboxyl groups of the modified dextran were determined using infrared spectroscopy, and the carboxyl contents were compared. The results of high-performance liquid chromatography indicated that dextran was degraded during the modification. The crystallization and the structure of the carboxyl-modified dextran were investigated using X-ray diffraction, nuclear magnetic resonance, and quadrupole time-of-flight mass spectrometry. The physicochemical properties, i.e., solubility, and granule morphology, of the carboxyl-modified dextran were carefully characterized and compared. This work provides a theoretical foundation for the accurate selection of carboxyl-modified dextran and the development of a novel strategy for the preparation of metal complexes.

中文翻译：

NaOH和NaClO / NaBr改性对葡聚糖结构和理化性质的影响

葡聚糖是具有高药用价值的多糖。因此，右旋糖酐的化学修饰及其衍生物的结构和物理化学性质应作为重点。葡聚糖（中号_W¯¯为5000道尔顿至7500道尔顿）可以与铁复合物。在这项研究中，右旋糖酐（M _w通过使用NaOH和NaClO / NaBr在不同的pH值（8–14）下对5400 Da）进行了修饰。使用红外光谱法测定修饰的葡聚糖的羧基，并比较羧基含量。高效液相色谱的结果表明，葡聚糖在修饰过程中被降解。使用X射线衍射，核磁共振和四极杆飞行时间质谱仪研究了羧基修饰的葡聚糖的结晶和结构。理化特性，即对羧基修饰的右旋糖酐的溶解度和颗粒形态进行了仔细的表征和比较。这项工作为准确选择羧基改性的右旋糖酐和开发一种制备金属配合物的新策略提供了理论基础。

更新日期：2018-03-16

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