Hybrid MoSe2–indocyanine green nanosheets as a highly efficient phototheranostic agent for photoacoustic imaging guided photothermal cancer therapy†,Biomaterials Science

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Hybrid MoSe2–indocyanine green nanosheets as a highly efficient phototheranostic agent for photoacoustic imaging guided photothermal cancer therapy†
Biomaterials Science ( IF 5.8 ) Pub Date : 2018-03-16 00:00:00 , DOI: 10.1039/c8bm00104a
Jingqin Chen _{1,

2,

3,

4,

5} , Xueshen Li _{1,

2,

3,

4,

5} , Xiaoyang Liu _{1,

2,

3,

4,

5} , Huixiang Yan _{1,

2,

3,

4,

5} , Zhihua Xie _{1,

2,

3,

4,

5} , Zonghai Sheng _{3,

4,

5,

6,

7} , Xiaojing Gong _{1,

2,

3,

4,

5} , Lidai Wang _{8,

9,

10,

11} , Xin Liu _{3,

4,

5,

6,

7} , Peng Zhang _{3,

4,

5,

7,

12} , Hairong Zheng _{3,

4,

5,

6,

7} , Liang Song _{1,

2,

3,

4,

5} , Chengbo Liu _{1,

2,

3,

4,

5}

Affiliation

Phototheranostic technology based on photoacoustic imaging (PAI) and photothermal therapy (PTT) is emerging as a powerful tool for tumor theranostic applications. For effective tumor eradication, a novel PAI/PTT theranostic nanoagent with an excellent optical absorption and photothermal capability is highly desired. Herein, we present a new PAI/PTT nanohybrid named sMoSe₂–ICG NSs by covalently conjugating aminated indocyanine green (ICG) onto a single layer of molybdenum selenide nanosheets (sMoSe₂ NSs). We first validate the sMoSe₂–ICG NS agent for the PAI and PTT effect in vitro and then use it for highly-sensitive PAI guided highly efficient tumor PTT in vivo. The sMoSe₂–ICG NS hybrid possesses several advantages for PAI/PTT applications: (1) the sMoSe₂–ICG NSs have strong absorbance in the broad near-infrared (NIR) region, enabling a highly efficient PAI/PTT theranostic effect and the selection of the most widely used excitation wavelength of 808 nm for PTT; (2) the photothermal ability of ICG in sMoSe₂–ICG NSs is augmented due to ICG aggregation induced fluorescence quenching and the re-absorbance of ICG fluorescence by sMoSe₂ NSs, which further enhances the PAI/PTT theranostic effect. (3) The characteristic absorption peak of sMoSe₂–ICG NSs is red-shifted compared to free ICG, resulting in a higher PAI signal-to-noise ratio (SNR) in vivo. Thus, combined with the good stability, high biocompatibility and minimal toxicity properties, the obtained sMoSe₂–ICG NSs hybrid has bright prospects for use in future PAI/PTT clinical applications.

中文翻译：

杂化MoSe _2-吲哚菁绿色纳米片作为一种高效的光热疗剂，用于光声成像指导的光热癌症治疗†

基于光声成像（PAI）和光热疗法（PTT）的光热疗技术正在成为肿瘤治疗学应用的强大工具。为了有效地消灭肿瘤，迫切需要具有优异的光吸收和光热能力的新型PAI / PTT治疗性纳米剂。在这里，我们通过将胺化的吲哚花青绿（ICG）共价共轭共轭到硒化钼纳米片（sMoSe ₂ NSs）的单层上，提出了一种新的PAI / PTT纳米复合物，称为sMoSe ₂ –ICG NSs 。我们首先在体外验证sMoSe ₂ –ICG NS剂对PAI和PTT的作用，然后将其用于体内高敏感度PAI指导的高效肿瘤PTT 。sMoSe ₂–ICG NS杂化物在PAI / PTT应用方面具有多个优势：（1）sMoSe ₂ –ICG NS在宽广的近红外（NIR）区域具有强吸收性，从而实现了高效的PAI / PTT人工诊断作用和选择PTT使用最广泛的808 nm激发波长；（2）sMoSe ₂ -ICG NSs中ICG的光热能力由于ICG聚集诱导的荧光猝灭和sMoSe ₂ NSs对ICG荧光的再吸收而增强，进一步增强了PAI / PTT的治疗作用。（3）sMoSe ₂ –ICG NSs的特征吸收峰与游离ICG相比发生了红移，从而导致体内更高的PAI信噪比（SNR）。因此，结合良好的稳定性，高生物相容性和极小的毒性，所得的sMoSe ₂ –ICG NSs杂种具有广阔的前景，可用于未来的PAI / PTT临床应用。

更新日期：2018-03-16

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