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Hybrid MoSe2–indocyanine green nanosheets as a highly efficient phototheranostic agent for photoacoustic imaging guided photothermal cancer therapy†
Biomaterials Science ( IF 5.8 ) Pub Date : 2018-03-16 00:00:00 , DOI: 10.1039/c8bm00104a
Jingqin Chen 1, 2, 3, 4, 5 , Xueshen Li 1, 2, 3, 4, 5 , Xiaoyang Liu 1, 2, 3, 4, 5 , Huixiang Yan 1, 2, 3, 4, 5 , Zhihua Xie 1, 2, 3, 4, 5 , Zonghai Sheng 3, 4, 5, 6, 7 , Xiaojing Gong 1, 2, 3, 4, 5 , Lidai Wang 8, 9, 10, 11 , Xin Liu 3, 4, 5, 6, 7 , Peng Zhang 3, 4, 5, 7, 12 , Hairong Zheng 3, 4, 5, 6, 7 , Liang Song 1, 2, 3, 4, 5 , Chengbo Liu 1, 2, 3, 4, 5
Affiliation  

Phototheranostic technology based on photoacoustic imaging (PAI) and photothermal therapy (PTT) is emerging as a powerful tool for tumor theranostic applications. For effective tumor eradication, a novel PAI/PTT theranostic nanoagent with an excellent optical absorption and photothermal capability is highly desired. Herein, we present a new PAI/PTT nanohybrid named sMoSe2–ICG NSs by covalently conjugating aminated indocyanine green (ICG) onto a single layer of molybdenum selenide nanosheets (sMoSe2 NSs). We first validate the sMoSe2–ICG NS agent for the PAI and PTT effect in vitro and then use it for highly-sensitive PAI guided highly efficient tumor PTT in vivo. The sMoSe2–ICG NS hybrid possesses several advantages for PAI/PTT applications: (1) the sMoSe2–ICG NSs have strong absorbance in the broad near-infrared (NIR) region, enabling a highly efficient PAI/PTT theranostic effect and the selection of the most widely used excitation wavelength of 808 nm for PTT; (2) the photothermal ability of ICG in sMoSe2–ICG NSs is augmented due to ICG aggregation induced fluorescence quenching and the re-absorbance of ICG fluorescence by sMoSe2 NSs, which further enhances the PAI/PTT theranostic effect. (3) The characteristic absorption peak of sMoSe2–ICG NSs is red-shifted compared to free ICG, resulting in a higher PAI signal-to-noise ratio (SNR) in vivo. Thus, combined with the good stability, high biocompatibility and minimal toxicity properties, the obtained sMoSe2–ICG NSs hybrid has bright prospects for use in future PAI/PTT clinical applications.

中文翻译:

杂化MoSe 2-吲哚菁绿色纳米片作为一种高效的光热疗剂,用于光声成像指导的光热癌症治疗

基于光声成像(PAI)和光热疗法(PTT)的光热疗技术正在成为肿瘤治疗学应用的强大工具。为了有效地消灭肿瘤,迫切需要具有优异的光吸收和光热能力的新型PAI / PTT治疗性纳米剂。在这里,我们通过将胺化的吲哚花青绿(ICG)共价共轭共轭到硒化钼纳米片(sMoSe 2 NSs)的单层上,提出了一种新的PAI / PTT纳米复合物,称为sMoSe 2 –ICG NSs 。我们首先在体外验证sMoSe 2 –ICG NS剂对PAI和PTT的作用,然后将其用于体内高敏感度PAI指导的高效肿瘤PTT 。sMoSe 2–ICG NS杂化物在PAI / PTT应用方面具有多个优势:(1)sMoSe 2 –ICG NS在宽广的近红外(NIR)区域具有强吸收性,从而实现了高效的PAI / PTT人工诊断作用和选择PTT使用最广泛的808 nm激发波长;(2)sMoSe 2 -ICG NSs中ICG的光热能力由于ICG聚集诱导的荧光猝灭和sMoSe 2 NSs对ICG荧光的再吸收而增强,进一步增强了PAI / PTT的治疗作用。(3)sMoSe 2 –ICG NSs的特征吸收峰与游离ICG相比发生了红移,从而导致体内更高的PAI信噪比(SNR)。因此,结合良好的稳定性,高生物相容性和极小的毒性,所得的sMoSe 2 –ICG NSs杂种具有广阔的前景,可用于未来的PAI / PTT临床应用。
更新日期:2018-03-16
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