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Highly emissive salicylidene Schiff bases (SASBs) in solution and their application in the detection of the chemical warfare agent mimic diethyl chlorophosphate†
Analytical Methods ( IF 2.7 ) Pub Date : 2018-03-16 00:00:00 , DOI: 10.1039/c8ay00050f Huan Liu 1, 2, 3 , Yanyan Fu 3, 4, 5, 6, 7 , Ao Liu 3, 4, 5, 6, 7 , Yaguo Yu 3, 4, 5, 6, 7 , Qingguo He 3, 4, 5, 6, 7 , Huimin Cao 3, 4, 5, 6, 7 , Jiangong Cheng 1, 2, 3, 4, 5
Analytical Methods ( IF 2.7 ) Pub Date : 2018-03-16 00:00:00 , DOI: 10.1039/c8ay00050f Huan Liu 1, 2, 3 , Yanyan Fu 3, 4, 5, 6, 7 , Ao Liu 3, 4, 5, 6, 7 , Yaguo Yu 3, 4, 5, 6, 7 , Qingguo He 3, 4, 5, 6, 7 , Huimin Cao 3, 4, 5, 6, 7 , Jiangong Cheng 1, 2, 3, 4, 5
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Salicylidene Schiff bases (SASBs) have attracted significant attention because they have unique properties and can be simply synthesized by the condensation reactions; however, their poor fluorescence in solution makes them unable to be used as a fluorescent turn-off probe and limits their application fields. Herein, we have endeavoured to design and synthesize salicylidene Schiff bases with strong fluorescence in solution by structural modification. We found that although 3,5-dibromosalicylidene 2,3,4,5,6-pentafluoroaniline (DBPFA) showed very poor luminescence properties in solution, when it was reacted with NaOH to afford DBPFA-I at the same concentration, the emission intensity of DBPFA-I was 3890 times that of DBPFA. DBPFA-I could be used for detection of the nerve agent sarin mimic diethyl chlorophosphate (DCP) via nucleophilic attack of phenolic anion to DCP. The detection limit of the probe could be as low as 1.94 nM, which was much lower than other detection results. In addition, a paper strip device of DBPFA-I became non emissive immediately (in <15 s) upon exposure to DCP vapour (132 ppm (v/v)) with excellent selectivity. The sensing mechanism was explored by analyzing the sample via mass spectrometry.
中文翻译：
溶液中的高发射性水杨基席夫碱（SASB）及其在化学战剂模拟物二氯氯磷酸†的检测中的应用†
亚水杨基席夫碱（SASBs）备受关注，因为它们具有独特的性能并且可以通过缩合反应简单地合成。然而，它们在溶液中的荧光差使它们不能用作荧光关闭探针，并限制了其应用领域。在本文中，我们努力通过结构修饰来设计和合成在溶液中具有强荧光的水杨基席夫碱。我们发现，虽然3,5-二溴水杨基2,3,4,5,6-五氟苯胺（DBPFA）在溶液中显示出很差的发光性能，但是当它与NaOH反应得到相同浓度的DBPFA-I时，发射强度的DBPFA，我是3890次DBPFA。DBPFA-1可通过酚类阴离子对DCP的亲核攻击而用于检测神经毒药沙林模拟物二氯乙基磷酸酯（DCP）。探针的检测限可能低至1.94 nM，远低于其他检测结果。另外，DBPFA-1的纸带装置在暴露于DCP蒸气（132 ppm（v / v））时立即具有极好的选择性（<15 s）不发光。通过质谱分析样品来探索传感机制。
更新日期：2018-03-16
中文翻译：
溶液中的高发射性水杨基席夫碱（SASB）及其在化学战剂模拟物二氯氯磷酸†的检测中的应用†
亚水杨基席夫碱（SASBs）备受关注，因为它们具有独特的性能并且可以通过缩合反应简单地合成。然而，它们在溶液中的荧光差使它们不能用作荧光关闭探针，并限制了其应用领域。在本文中，我们努力通过结构修饰来设计和合成在溶液中具有强荧光的水杨基席夫碱。我们发现，虽然3,5-二溴水杨基2,3,4,5,6-五氟苯胺（DBPFA）在溶液中显示出很差的发光性能，但是当它与NaOH反应得到相同浓度的DBPFA-I时，发射强度的DBPFA，我是3890次DBPFA。DBPFA-1可通过酚类阴离子对DCP的亲核攻击而用于检测神经毒药沙林模拟物二氯乙基磷酸酯（DCP）。探针的检测限可能低至1.94 nM，远低于其他检测结果。另外，DBPFA-1的纸带装置在暴露于DCP蒸气（132 ppm（v / v））时立即具有极好的选择性（<15 s）不发光。通过质谱分析样品来探索传感机制。
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