A concise and efficient one-pot strategy to synthesize 3-fluoroflavones was developed. 1-(2-Hydroxyphenyl)-3-phenylpropane-1,3-diones were fluorinated using selectfluor with a small amount of CH₃CN at room temperature, followed by cyclization and dehydration in the presence of a trace amount of conc. H₂SO₄ to provide 3-fluoroflavones. The desired 3-fluoroflavone analogues were obtained in moderate to excellent yields. This strategy tolerated a wide range of functional groups and did not need sophisticated instruments or tedious substrate preparation.

中文翻译：

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在室温下通过1-（2-羟苯基）-3-苯基丙烷-1,3-二酮和selectfluor 一锅合成3-氟黄酮†

开发了一种简洁高效的一锅法合成3-氟黄酮。在室温下，使用带有少量CH ₃ CN的selectfluor对1-（2-羟基苯基）-3-苯基丙烷-1,3-二酮进行氟化，然后在痕量浓盐酸存在下进行环化和脱水。H ₂ SO ₄提供3-氟黄酮。以中等至优异的产率获得了所需的3-氟黄酮类似物。该策略可耐受各种官能团，不需要复杂的仪器或繁琐的底物制备。