Most animals undergo homeostatic tissue maintenance, yet those capable of robust regeneration in adulthood use mechanisms significantly overlapping with homeostasis. Here we show in planarians that modulations to body-wide patterning systems shift the target site for eye regeneration while still enabling homeostasis of eyes outside this region. The uncoupling of homeostasis and regeneration, which can occur during normal positional rescaling after axis truncation, is not due to altered injury signaling or stem cell activity, nor specific to eye tissue. Rather, pre-existing tissues, which are misaligned with patterning factor expression domains, compete with properly located organs for incorporation of migratory progenitors. These observations suggest that patterning factors determine sites of organ regeneration but do not solely determine the location of tissue homeostasis. These properties provide candidate explanations for how regeneration integrates pre-existing tissues and how regenerative abilities could be lost in evolution or development without eliminating long-term tissue maintenance and repair.

中文翻译：

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位置信息指定涡虫的器官再生部位而不是组织维持

大多数动物都经历稳态组织维持，但那些能够在成年期强健再生的动物使用机制与稳态显着重叠。在这里，我们在涡虫中展示了对全身图案系统的调制改变了眼睛再生的目标位点，同时仍然使该区域外的眼睛保持稳态。体内平衡和再生的解耦，在轴截断后的正常位置重新缩放期间可能发生，不是由于损伤信号或干细胞活性的改变，也不是特定于眼组织。相反，与模式化因子表达域错位的预先存在的组织与正确定位的器官竞争以掺入迁移祖细胞。这些观察结果表明，模式因素决定了器官再生的部位，但并不仅仅决定了组织稳态的位置。这些特性为再生如何整合预先存在的组织以及在不消除长期组织维护和修复的情况下如何在进化或发育中丧失再生能力提供了候选解释。