Porous Poly(vinyl alcohol)-Based Hydrogel for Knee Meniscus Functional Repair,ACS Biomaterials Science & Engineering

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Porous Poly(vinyl alcohol)-Based Hydrogel for Knee Meniscus Functional Repair
ACS Biomaterials Science & Engineering ( IF 5.4 ) Pub Date : 2018-03-15 00:00:00 , DOI: 10.1021/acsbiomaterials.7b00879
Luca Coluccino ₁ , Riccardo Gottardi _{1,

2} , Farouk Ayadi ₃ , Athanassia Athanassiou , Rocky S. Tuan ₁ , Luca Ceseracciu

Affiliation

The meniscus has a key role within the knee joint, conferring stability, absorbing and redistributing loads, and influencing the overall movement proprioception. Recent developments in the treatment of meniscal injury have progressively shifted the focus from general resection to functional repair, with the recognition that restoring the biomechanical meniscal function helps to prevent degenerative changes in the knee joint and the insurgence of osteoarthritis. To address this clinical need, we have developed a biomimetic implant based on a porous poly(vinyl alcohol) (PVA) hydrogel. Such hydrogels are stable, biocompatible, and suitable to surgical translation, and their mechanical properties can be tuned to reduce the mismatch in the case of partial meniscectomy. The PVA implant structure is porous and permeable, allowing fluid flows and facilitating anatomical integration in situ. Here, we present a chemo-physical characterization of PVA porous hydrogels, focusing on their tunable morphology and associated viscoelastic properties. Biocompatibility was evaluated using primary bovine meniscal fibrochondrocytes, and integration with native tissues was assessed in an ex vivo model. Overall, our results suggest that a synthetic meniscal implant based on a porous PVA hydrogel could restore the physiological function of the meniscus and represent a promising clinical alternative to current resection treatments.

中文翻译：

多孔聚乙烯醇基水凝胶用于膝半月板功能修复

半月板在膝关节内起关键作用，赋予稳定性，吸收和重新分配负荷并影响整体运动的本体感觉。在认识到恢复生物力学半月板功能有助于防止膝关节的退行性改变和骨关节炎的退缩方面，半月板损伤治疗的最新进展已将重点从一般切除转向功能性修复。为了满足这一临床需求，我们开发了一种基于多孔聚乙烯醇（PVA）水凝胶的仿生植入物。这样的水凝胶是稳定的，生物相容的，并且适合于手术翻译，并且在半月板切除术的情况下，可以调节它们的机械性能以减少失配。PVA植入物结构是多孔且可渗透的，允许流体流动并促进原位解剖整合。在这里，我们介绍了PVA多孔水凝胶的化学物理特性，重点是其可调谐的形态和相关的粘弹性。使用原发性牛半月板纤维软骨细胞评估生物相容性，并在离体模型中评估与天然组织的整合。总体而言，我们的结果表明，基于多孔PVA水凝胶的合成半月板植入物可以恢复半月板的生理功能，并代表了当前切除治疗的有希望的临床替代方法。使用原发性牛半月板纤维软骨细胞评估生物相容性，并在离体模型中评估与天然组织的整合。总体而言，我们的结果表明，基于多孔PVA水凝胶的合成半月板植入物可以恢复半月板的生理功能，并代表了当前切除治疗的有希望的临床替代方法。使用原发性牛半月板纤维软骨细胞评估生物相容性，并在离体模型中评估与天然组织的整合。总体而言，我们的结果表明，基于多孔PVA水凝胶的合成半月板植入物可以恢复半月板的生理功能，并代表了当前切除治疗的有希望的临床替代方法。

更新日期：2018-03-15

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