Multidimensional Inverse Laplace Transform (ILT) NMR methods have established themselves over the last two decades in material science, engineering, medical research and industry. Here we report on two variants of the two-dimensional (2D) Diffusion-Diffusion Correlation Spectroscopy (DDCOSY) which allows for the correlation of molecular displacements in different directions, thus sampling local mobility and confinement. The first variant aims to measure Fractional Anisotropy (FA) averaged over the whole sample which can be extracted from the DDCOSY results using a particular gradient orientation scheme. We demonstrate that this method returns averaged FA values which are consistent with DTI measurements. The second variant concerns a shortened version of the DDCOSY (sDDCOSY) experiment for which gradients in the two different directions are applied at the same time. This shortened DDCOSY version may proof indispensable for samples with short $T_2$ relaxation times.

过去二十年来，多维逆拉普拉斯逆变换（ILT）NMR方法已在材料科学，工程，医学研究和工业领域确立了自己的地位。在这里，我们报告了二维（2D）扩散-扩散相关光谱法（DDCOSY）的两个变体，该变体允许分子位移在不同方向上的相关性，从而对局部迁移率和封闭度进行了采样。第一个变量旨在测量整个样本的平均分数各向异性（FA），该分数可以使用特定的梯度方向方案从DDCOSY结果中提取。我们证明该方法返回与DTI测量值一致的平均FA值。第二个变体涉及DDCOSY（sDDCOSY）实验的简化版本，该实验同时在两个不同方向上应用了渐变。缩短版的DDCOSY版本可能对于缺少样品的样品可能是必不可少的${Ť}_{\mathrm{2个}}$ 放松时间。