Invasive fungal diseases pose a serious threat, and new drugs are urgently needed. In this issue ofCell Chemical Biology,Pries et al. (2018)identified benzamide- and picolinamide-based small-molecule inhibitors with antifungal properties, including some active against pathogenicCandidaspecies. These compounds target an essential component of the fungal secretion machinery, suggesting a new approach to antifungal development.

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真菌分泌：抗真菌剂的下一代目标？

侵袭性真菌疾病构成严重威胁，因此迫切需要新药。在本期《细胞化学生物学》中，Pries等人。（2018）确定了具有抗真菌特性的基于苯甲酰胺和吡啶甲酰胺的小分子抑制剂，其中包括一些对致病性念珠菌具有活性的物质。这些化合物靶向真菌分泌机制的重要组成部分，表明了抗真菌发育的新方法。