Analysis of Human Sequence Data Reveals Two Pulses of Archaic Denisovan Admixture.,Cell

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Analysis of Human Sequence Data Reveals Two Pulses of Archaic Denisovan Admixture.
Cell ( IF 45.5 ) Pub Date : 2018-Mar-22 , DOI: 10.1016/j.cell.2018.02.031
Sharon R Browning ₁ , Brian L Browning ₂ , Ying Zhou ₁ , Serena Tucci ₃ , Joshua M Akey ₄

Affiliation

Anatomically modern humans interbred with Neanderthals and with a related archaic population known as Denisovans. Genomes of several Neanderthals and one Denisovan have been sequenced, and these reference genomes have been used to detect introgressed genetic material in present-day human genomes. Segments of introgression also can be detected without use of reference genomes, and doing so can be advantageous for finding introgressed segments that are less closely related to the sequenced archaic genomes. We apply a new reference-free method for detecting archaic introgression to 5,639 whole-genome sequences from Eurasia and Oceania. We find Denisovan ancestry in populations from East and South Asia and Papuans. Denisovan ancestry comprises two components with differing similarity to the sequenced Altai Denisovan individual. This indicates that at least two distinct instances of Denisovan admixture into modern humans occurred, involving Denisovan populations that had different levels of relatedness to the sequenced Altai Denisovan. VIDEO ABSTRACT.

中文翻译：

人类序列数据分析揭示了古老丹尼索瓦人混合物的两个脉冲。

解剖学上的现代人类与尼安德特人以及与丹尼索瓦人相关的古代人群杂交。几个尼安德特人和一个丹尼索瓦人的基因组已被测序，这些参考基因组已被用来检测当今人类基因组中渗入的遗传物质。基因渗入片段也可以在不使用参考基因组的情况下进行检测，这样做有利于发现与测序的古基因组不太密切相关的基因渗入片段。我们应用一种新的无参考方法来检测来自欧亚大陆和大洋洲的 5,639 个全基因组序列的古老基因渗入。我们在东亚、南亚和巴布亚的人群中发现了丹尼索瓦人的血统。丹尼索瓦人的血统由两个组成部分组成，与已测序的阿尔泰丹尼索瓦人具有不同的相似性。这表明至少有两个不同的丹尼索瓦人与现代人类混合的例子，涉及与已测序的阿尔泰丹尼索瓦人具有不同程度的相关性的丹尼索瓦人群体。视频摘要。

更新日期：2018-03-16

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