Meristems contain groups of indeterminate stem cells, which are maintained by a feedback loop between CLAVATA (CLV) and WUSCHEL (WUS) signaling. CLV signaling involves the secretion of the CLV3 peptide and its perception by a number of Leucine-Rich-Repeat (LRR) receptors, including the receptor-like kinase CLV1 and the receptor-like protein CLV2 coupled with the CORYNE (CRN) pseudokinase. CLV2, and its maize ortholog FASCIATED EAR2 (FEA2) appear to function in signaling by CLV3 and several related CLV3/EMBRYO-SURROUNDING REGION (CLE) peptide ligands. Nevertheless, how signaling specificity is achieved remains unknown. Here we show that FEA2 transmits signaling from two distinct CLE peptides, the maize CLV3 ortholog ZmCLE7 and ZmFON2-LIKE CLE PROTEIN1 (ZmFCP1) through two different candidate downstream effectors, the alpha subunit of the maize heterotrimeric G protein COMPACT PLANT2 (CT2), and ZmCRN. Our data provide a novel framework to understand how diverse signaling peptides can activate different downstream pathways through common receptor proteins.

中文翻译：

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CLAVATA 受体 FASCIATED EAR2 通过通过两个下游效应器发出信号来响应不同的 CLE 肽

分生组织包含一组不确定的干细胞，它们由 CLAVATA (CLV) 和 WUSCHEL (WUS) 信号之间的反馈回路维持。CLV 信号传导涉及 CLV3 肽的分泌及其被许多富含亮氨酸重复 (LRR) 受体的感知，包括受体样激酶 CLV1 和与 CORYNE (CRN) 假激酶偶联的受体样蛋白 CLV2。CLV2 及其玉米直系同源物 FASCIATED EAR2 (FEA2) 似乎在 CLV3 和几个相关的 CLV3/胚胎周围区域 (CLE) 肽配体的信号传导中起作用。然而，如何实现信号特异性仍然未知。在这里，我们展示了 FEA2 通过两种不同的候选下游效应子传递来自两种不同 CLE 肽的信号，即玉米 CLV3 直系同源物 ZmCLE7 和 ZmFON2-LIKE CLE PROTEIN1 (ZmFCP1)，玉米异源三聚体 G 蛋白 COMPACT PLANT2 (CT2) 和 ZmCRN 的 α 亚基。我们的数据提供了一个新的框架来了解不同的信号肽如何通过常见的受体蛋白激活不同的下游通路。