Serum amyloid A sequesters diverse phospholipids and their hydrolytic products, hampering fibril formation and proteolysis in a lipid-dependent manner†,Chemical Communications

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Serum amyloid A sequesters diverse phospholipids and their hydrolytic products, hampering fibril formation and proteolysis in a lipid-dependent manner†
Chemical Communications ( IF 4.3 ) Pub Date : 2018-03-15 00:00:00 , DOI: 10.1039/c8cc01424h
Shobini Jayaraman _{1,

2,

3,

4} , Donald L. Gantz _{1,

2,

3,

4} , Christian Haupt _{5,

6,

7,

8} , Marcus Fändrich _{5,

6,

7,

8} , Olga Gursky _{1,

2,

3,

4}

Affiliation

Serum amyloid A action in immune response and deposition in inflammation-linked amyloidosis involve SAA–lipid interactions. We show that SAA sequesters neutral and anionic phospholipids and their hydrolytic products to form nanoparticles, suggesting a synergy with phospholipase A₂. The lipid charge and shape affect SAA protection from proteolysis, aggregation and fibrillogenesis.

中文翻译：

血清淀粉样蛋白A螯合各种磷脂及其水解产物，以脂质依赖性方式阻碍原纤维形成和蛋白水解†

血清淀粉样蛋白炎症相关淀粉样变性中免疫应答和沉积的作用涉及SAA-脂质相互作用。我们显示SAA螯合中性和阴离子磷脂及其水解产物以形成纳米颗粒，表明与磷脂酶A ₂协同作用。脂质的电荷和形状影响SAA对蛋白水解，聚集和原纤维形成的保护作用。

更新日期：2018-03-15

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