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Pleistocene North African genomes link Near Eastern and sub-Saharan African human populations
Science ( IF 56.9 ) Pub Date : 2018-03-15 , DOI: 10.1126/science.aar8380
Marieke van de Loosdrecht 1 , Abdeljalil Bouzouggar 2, 3 , Louise Humphrey 4 , Cosimo Posth 1 , Nick Barton 5 , Ayinuer Aximu-Petri 6 , Birgit Nickel 6 , Sarah Nagel 6 , El Hassan Talbi 7 , Mohammed Abdeljalil El Hajraoui 2 , Saaïd Amzazi 8 , Jean-Jacques Hublin 3 , Svante Pääbo 6 , Stephan Schiffels 1 , Matthias Meyer 6 , Wolfgang Haak 1 , Choongwon Jeong 1 , Johannes Krause 1
Affiliation  

Relationships among North Africans The general view is that Eurasians mostly descend from a single group of humans that dispersed outside of sub-Saharan Africa around 50,000 to 100,000 years ago. Present-day North Africans share a majority of their ancestry with present-day Near Easterners, but not with sub-Saharan Africans. To investigate this conundrum, Van de Loosdrecht et al. sequenced high-quality DNA obtained from bone samples of seven individuals from Taforalt in eastern Morocco dating from the Later Stone Age, about 15,000 years ago. The Taforalt individuals were found to be most closely related to populations from the Near East (Natufians), with a third of their ancestry from sub-Saharan Africa. No evidence was found for introgression with western Europeans, despite attribution to the Iberomaurusian culture. None of the present-day or ancient Holocene African groups are a good proxy for the sub-Saharan genetic component. Science, this issue p. 548 Ancient human genomes suggest dynamic interactions among Pleistocene African populations. North Africa is a key region for understanding human history, but the genetic history of its people is largely unknown. We present genomic data from seven 15,000-year-old modern humans, attributed to the Iberomaurusian culture, from Morocco. We find a genetic affinity with early Holocene Near Easterners, best represented by Levantine Natufians, suggesting a pre-agricultural connection between Africa and the Near East. We do not find evidence for gene flow from Paleolithic Europeans to Late Pleistocene North Africans. The Taforalt individuals derive one-third of their ancestry from sub-Saharan Africans, best approximated by a mixture of genetic components preserved in present-day West and East Africans. Thus, we provide direct evidence for genetic interactions between modern humans across Africa and Eurasia in the Pleistocene.

中文翻译:

更新世北非基因组将近东和撒哈拉以南非洲人口联系起来

北非人之间的关系 一般的观点是,欧亚人大多来自大约 50,000 到 100,000 年前分散在撒哈拉以南非洲以外的单一人类群体。当今的北非人与当今的近东人拥有大部分血统,但与撒哈拉以南非洲人的血统不同。为了研究这个难题,Van de Loosdrecht 等人。对从大约 15,000 年前的晚期石器时代的摩洛哥东部 Taforalt 的七个个体的骨骼样本中获得的高质量 DNA 进行测序。发现 Taforalt 个体与来自近东(纳图菲亚人)的人口最密切相关,他们三分之一的血统来自撒哈拉以南非洲。尽管归因于伊比利亚龙文化,但没有发现西欧人基因渗入的证据。现代或古代全新世非洲群体都不是撒哈拉以南遗传成分的良好代表。科学,这个问题 p。548 古代人类基因组表明更新世非洲人口之间的动态相互作用。北非是了解人类历史的关键地区,但其人民的遗传历史在很大程度上是未知的。我们展示了来自摩洛哥的 7 个 15,000 年前现代人类的基因组数据,这些数据归因于伊比利亚龙文化。我们发现与全新世早期近东人的遗传亲缘关系,最好的代表是黎凡特纳图夫人,这表明非洲和近东之间存在前农业联系。我们没有发现基因从旧石器时代的欧洲人流向晚更新世北非人的证据。Taforalt 人三分之一的血统来自撒哈拉以南非洲人,最好通过保存在当今西非和东非人中的遗传成分的混合物来近似。因此,我们为更新世非洲和欧亚大陆的现代人类之间的遗传相互作用提供了直接证据。
更新日期:2018-03-15
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