Synthesis of New Indolizidine Derivatives from 1-(2-Quinolyl)-2-propen-1-ol,ACS Omega

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Synthesis of New Indolizidine Derivatives from 1-(2-Quinolyl)-2-propen-1-ol
ACS Omega ( IF 3.7 ) Pub Date : 2018-03-15 00:00:00 , DOI: 10.1021/acsomega.8b00167
Donatella Giomi ₁ , Jacopo Ceccarelli ₁ , Alberto Brandi ₁

Affiliation

The four-step procedure involving bromination, reduction, and nucleophilic substitution via elimination/addition previously applied to 1-(2-pyridyl)-2-propen-1-ol for the synthesis of indolizidine systems has now been extended to 1-(2-quinolyl)-2-propen-1-ol allowing a general access to benzo-fused derivatives. For instance, (±)-benzo[e]lentiginosine has been easily synthesized in an 18% overall yield.

中文翻译：

1-（2-喹啉）-2-丙烯-1-醇合成新的吲哚并咪唑衍生物

以前通过将消灭/加成反应用于溴化，还原和亲核取代的四步程序（以前已应用于1-（2-吡啶基）-2-丙烯-1-醇，用于合成吲哚唑烷系统）现已扩展为1-（2 -喹啉基）-2-丙烯-1-醇，通常可使用苯并稠合衍生物。例如，很容易以18％的总收率合成（±）-苯并[ e ]龙胆草碱。

更新日期：2018-03-15

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