Five new coordination polymers (CPs) namely, [{Zn(μ²-H₂O)_0.5(5N₃-IPA)(2,2′-bpe)}]_∞ (1), [{Zn(μ²-H₂O)_0.5(5N₃-IPA)(1,10-phen)}]_∞ (2), [{Zn(5N₃-IPA)(1,2-bpe)}]_∞ (3), [{Zn(5N₃-IPA)(1,2-bpey)}]_∞ (4), and [{Zn(H₂O)(5N₃-IPA)(4,4′-tme)}(H₂O)_0.5]_∞ (5) (5N₃-H₂IPA = 5-azidoisophthalic acid, 2,2′-bpe= 2,2′-bipyridine, 1,10-phen = 1,10-phenanthroline, 1,2-bpe = 1,2-bis(4-pyridyl)ethane, 1,2-bpey = 1,2-bis(4-pyridyl)ethylene, 4,4′-tme = 4,4′-trimethylenedipyridine), have been synthesized based on a mixed ligand approach adopting a solvothermal technique. Depending upon the intrinsic structural flexibility of the bis-pyridyl coligands, interesting structural topologies have also been observed in the resulting CPs: Sra SrAl2 type topology for 3 and a 3-fold interpenetrated dmp topology for 4. A green hand grinding technique has been implemented to reduce the particle size of the CPs to generate nanoscale CPs (NCPs). SEM studies of NCPs reveal the formation of square and spherical particles for NCP 1 and 2, respectively, and nano rod for NCP 3, 4, and 5. Remarkably, when scaled down to nano range all the NCPs retain their crystalline nature. The cytotoxic activity of the NCPs (1-5) has been studied using human colorectal carcinoma cells (HCT 116). Significant cell death is observed for NCP 2, which is further corroborated by cell growth inhibition study. The observed cell death is likely to be due to mitochondrial-assisted apoptosis as is evident from immunofluorescence study.

中文翻译：

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绿色方法合成晶体纳米级Zn ^II-配位聚合物：细胞生长抑制和免疫荧光研究

五个新的配位聚合物（CPS），即[{锌（μ ² -H ₂ O）_0.5（5N ₃ -ipa）（2,2'- BPE）}] _∞（1），[{锌（μ ² -H ₂ O）_0.5（5N ₃ -IPA）（1,10-phen）}] _∞（2），[{Zn（5N ₃ -IPA）（1,2-bpe）}] _∞（3），[{Zn （5N ₃ -IPA）（1,2-bpey）}] _∞（4）和[{Zn（H ₂ O）（5N ₃ -IPA）（4,4'-tme）}（H ₂ O）_0.5 ] _∞（5）（5N ₃ -H ₂ IPA = 5-叠氮基间苯二甲酸，2,2'-bpe = 2,2'-联吡啶，1,10-phen = 1,10-菲咯啉，1,2-bpe = 1,2 -双（4-吡啶基）乙烷，1,2-bpey = 1,2-双（4-吡啶基）乙烯，4,4'-tme = 4,4'-三亚甲基二吡啶）采用溶剂热技术的方法。取决于双吡啶基共配体的固有结构的灵活性，有趣的结构拓扑学也已在所得的CP观察：SRA SrAl2类型的拓扑为3和3倍互穿DMP拓扑4。已经实施了绿色手磨技术以减小CP的粒度以产生纳米级CP（NCP）。的NCP的SEM研究表明平方和球状粒子为NCP的形成1和2分别和纳米棒NCP 3，4，和5。值得注意的是，当缩小到纳米范围时，所有NCP都保留其晶体性质。所述的NCP的细胞毒性活性（1 - 5）已被使用人大肠癌细胞（HCT 116）研究。NCP 2观察到明显的细胞死亡细胞生长抑制研究进一步证实了这一点。免疫荧光研究表明，观察到的细胞死亡很可能是由于线粒体辅助的细胞凋亡。