Asymmetric total syntheses of callistrilones B, G and J†,Organic Chemistry Frontiers

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Asymmetric total syntheses of callistrilones B, G and J†
Organic Chemistry Frontiers ( IF 4.6 ) Pub Date : 2018-03-15 00:00:00 , DOI: 10.1039/c8qo00130h
Li-Jun Hu _{1,

2,

3,

4} , Min-Jing Cheng _{4,

5,

6,

7,

8} , Jia-Qing Cao _{4,

5,

6,

7} , Li-Ping Zhong _{4,

8,

9,

10} , Ya-Jian Hu _{4,

8,

9,

10} , Ying Wang _{4,

5,

6,

7} , Lei Wang _{4,

5,

6,

7} , Wen-Cai Ye _{1,

2,

3,

4,

5} , Chuang-Chuang Li _{4,

8,

9,

10}

Affiliation

A very concise approach for the first asymmetric and scalable total syntheses of callistrilones B, G and J has been developed. These syntheses proceeded in only 3–4 steps from the commercially available (−)-α-phellandrene (8), without the need for protecting groups. The key feature of the syntheses was a biomimetic, diastereo- and regioselective oxidative [3 + 2] cycloaddition.

中文翻译：

Callistrilones B，G和J的不对称总合成†

已经开发出一种非常简洁的方法来用于Callistrilones B，G和J的第一个不对称和可扩展的总合成。从市售（-）-α-芹烯（8）进行这些合成仅需3-4步，而无需保护基团。合成的关键特征是仿生，非对映和区域选择性氧化[3 + 2]环加成反应。

更新日期：2018-03-15

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