Novel functionalized organotellurides with enhanced thiol peroxidase catalytic activity†,New Journal of Chemistry

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Novel functionalized organotellurides with enhanced thiol peroxidase catalytic activity†
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2018-03-15 00:00:00 , DOI: 10.1039/c8nj00700d
Damiano Tanini _{1,

2,

3,

4} , Anna Grechi _{1,

2,

3,

4} , Lorenzo Ricci _{1,

2,

3,

4} , Silvia Dei _{2,

5,

6,

7,

8} , Elisabetta Teodori _{2,

5,

6,

7,

8} , Antonella Capperucci _{1,

2,

3,

4}

Affiliation

The thiol peroxidase-like activity of a series of novel functionalized tellurium containing catalysts has been investigated with different models. Dialkyl- and aryl-alkyl-tellurides, conveniently achieved through the ring opening of strained heterocycles, exhibited remarkable catalytic antioxidant activity, being able to reduce hydrogen peroxide in the presence of different thiols (benzenethiol, dithiothreitol and glutathione) under different conditions. The nature of the β-substituent strongly influenced the performances of the studied catalysts, thus giving useful criteria for the design of good synthetic mimics of glutathione peroxidase. The catalytic activity of functionalized organotellurides has been compared with that of their selenated analogues, showing as the latter behave as less efficient catalysts.

中文翻译：

具有增强的巯基过氧化物酶催化活性的新型功能化有机碲化物†

已经用不同的模型研究了一系列新型的功能化的含碲催化剂的硫醇过氧化物酶样活性。通过紧张的杂环的开环方便地获得的二烷基-和芳基-烷基-碲化物，表现出显着的催化抗氧化活性，能够在不同条件下在不同硫醇（苯硫醇，二硫苏糖醇和谷胱甘肽）存在下还原过氧化氢。β-取代基的性质极大地影响了所研究催化剂的性能，从而为设计谷胱甘肽过氧化物酶的良好合成模拟物提供了有用的标准。已将官能化的有机碲化物与其硒化类似物的催化活性进行了比较，显示后者的催化活性较低。

更新日期：2018-03-15

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