Triflic acid-catalyzed metal-free synthesis of (E)-2-cyanoacrylamides and 3-substituted azetidine-2,4-diones†,New Journal of Chemistry

当前位置： X-MOL 学术 › New J. Chem. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Triflic acid-catalyzed metal-free synthesis of (E)-2-cyanoacrylamides and 3-substituted azetidine-2,4-diones†
New Journal of Chemistry ( IF 2.7 ) Pub Date : 2018-03-15 00:00:00 , DOI: 10.1039/c7nj05169g
Bapurao D. Rupanwar _{1,

2,

3,

4} , Santosh S. Chavan _{1,

2,

3,

4} , Anil M. Shelke _{1,

2,

3,

4} , Gurunath M. Suryavanshi _{1,

2,

3,

4}

Affiliation

A TfOH-catalyzed highly efficient synthesis of biologically active (E)-2-cyanoacrylamides and 3-substituted azetidine-2,4-diones has been reported with 64–94% yields under metal-free conditions. The reaction proceeds through sequential Knoevenagel condensation/stereoselective in situ monohydration of nitrile or C–N cyclization protocol in one-pot. The attractive features of this tandem process are moderate reaction conditions, high atom economy, broad substrate scope, gram-scale reaction and ease of operation.

中文翻译：

三氟甲磺酸催化的无金属合成（E）-2-氰基丙烯酰胺和3-取代的氮杂环丁烷2,4-二酮†

据报道，在无金属条件下，TfOH催化可高效合成具有生物活性的（E）-2-氰基丙烯酰胺和3-取代的氮杂环丁烷2,4-二酮，收率为64-94％。反应通过一锅顺序进行的Knoevenagel缩合反应/腈选择性地原位单水合或CN环化方案进行。该串联方法的吸引人的特征是中等反应条件，高原子经济性，广泛的底物范围，克级反应和易于操作。

更新日期：2018-03-15

点击分享查看原文

点击收藏

阅读更多本刊最新论文本刊介绍/投稿指南11