Rocuronium is a neuromuscular blocking agent used in anesthesia to facilitate tracheal intubation by muscle relaxation. A fast and sensitive amperometric sensor was developed for the detection of rocuronium in human whole blood samples. The sensor probe was fabricated using phosphatidylinositol lipid (PI) bonded 3′-(2-aminopyrimidyl)-2,2′ : 5′,2′′-terthiophene and porous carbon, which revealed the enhanced response to the rocuronium oxidation. The modified sensor layers were characterized by electrochemical and surface analysis experiments. The experimental parameters affecting the rocuronium analysis were studied in terms of PI concentration, amount of porous carbon, pH, temperature, and interferences. A dynamic range was observed between 0.025 to 10 μg/mL with the detection limit of 3.83±0.21 ng/mL. The reliability of proposed sensor was successfully demonstrated through the detection of rocuronium in clinical samples without pre-treatment.

中文翻译：

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使用脂质键合导电聚合物和多孔碳复合电极检测全血中的罗库溴铵

罗库溴铵是一种用于麻醉的神经肌肉阻滞剂，通过肌肉松弛促进气管插管。开发了一种快速灵敏的电流传感器，用于检测人类全血样品中的罗库溴铵。传感器探针是使用结合 3'-(2-氨基嘧啶基)-2,2': 5',2''-三噻吩和多孔碳的磷脂酰肌醇脂质 (PI) 制成的，这表明对罗库溴铵氧化的响应增强。通过电化学和表面分析实验表征改性的传感器层。研究了影响罗库溴铵分析的实验参数，包括 PI 浓度、多孔碳量、pH 值、温度和干扰。在 0.025 至 10 μg/mL 之间观察到动态范围，检测限为 3.83±0.21 ng/mL。