当前位置：
X-MOL 学术
›
Adv. Healthcare Mater.
›
论文详情
Our official English website, www.x-mol.net, welcomes your
feedback! (Note: you will need to create a separate account there.)
Current Concepts in Meniscus Tissue Engineering and Repair
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-03-15 , DOI: 10.1002/adhm.201701407 Bahar Bilgen 1, 2 , Chathuraka T Jayasuriya 1 , Brett D Owens 1
Advanced Healthcare Materials ( IF 10.0 ) Pub Date : 2018-03-15 , DOI: 10.1002/adhm.201701407 Bahar Bilgen 1, 2 , Chathuraka T Jayasuriya 1 , Brett D Owens 1
Affiliation
|
The meniscus is the most commonly injured structure in the human knee. Meniscus deficiency has been shown to lead to advanced osteoarthritis (OA) due to abnormal mechanical forces, and replacement strategies for this structure have lagged behind other tissue engineering endeavors. The challenges include the complex 3D structure with individualized size parameters, the significant compressive, tensile and shear loads encountered, and the poor blood supply. In this progress report, a review of the current clinical treatments for different types of meniscal injury is provided. The state‐of‐the‐art research in cellular therapies and novel cell sources for these therapies is discussed. The clinically available cell‐free biomaterial implants and the current progress on cell‐free biomaterial implants are reviewed. Cell‐based tissue engineering strategies for the repair and replacement of meniscus are presented, and the current challenges are identified. Tissue‐engineered meniscal biocomposite implants may provide an alternative solution for the treatment of meniscal injury to prevent OA in the long run, because of the limitations of the existing therapies.
中文翻译：
半月板组织工程和修复的最新概念
半月板是人类膝盖中最常受伤的结构。半月板缺陷已被证明会因异常机械力而导致晚期骨关节炎（OA），而这种结构的替代策略已经落后于其他组织工程的努力。挑战包括具有个性化尺寸参数的复杂 3D 结构、遇到的显着压缩、拉伸和剪切载荷以及血液供应不良。在这份进展报告中，对当前不同类型半月板损伤的临床治疗进行了回顾。讨论了细胞疗法的最新研究和这些疗法的新型细胞来源。对临床上可用的无细胞生物材料植入物以及目前无细胞生物材料植入物的进展进行了综述。提出了用于修复和替换半月板的基于细胞的组织工程策略，并确定了当前的挑战。由于现有疗法的局限性，从长远来看，组织工程半月板生物复合植入物可能为治疗半月板损伤以预防骨关节炎提供替代解决方案。
更新日期：2018-03-15
中文翻译：
半月板组织工程和修复的最新概念
半月板是人类膝盖中最常受伤的结构。半月板缺陷已被证明会因异常机械力而导致晚期骨关节炎（OA），而这种结构的替代策略已经落后于其他组织工程的努力。挑战包括具有个性化尺寸参数的复杂 3D 结构、遇到的显着压缩、拉伸和剪切载荷以及血液供应不良。在这份进展报告中，对当前不同类型半月板损伤的临床治疗进行了回顾。讨论了细胞疗法的最新研究和这些疗法的新型细胞来源。对临床上可用的无细胞生物材料植入物以及目前无细胞生物材料植入物的进展进行了综述。提出了用于修复和替换半月板的基于细胞的组织工程策略，并确定了当前的挑战。由于现有疗法的局限性，从长远来看，组织工程半月板生物复合植入物可能为治疗半月板损伤以预防骨关节炎提供替代解决方案。
京公网安备 11010802027423号