Direct DNA sensor based on new nanocomposite materials (Fc-ac-OMPA/MWCNTs) has been investigated. This nanocomposite was formed by combining the redox oligomer “oligo-methoxy-phenyl-acetonitrile” (Fc-ac-OMPA) and the MWCNTs via a simple π-π stacking interaction in the aim to ameliorate the biosensor performance. The redox indicator and the functional groups of the redox oligomer have been used for monitoring the electrochemical behavior and the flexibility for direct covalent attachment of Hepatitis C DNA probe. This nanocomposite shows high performance of DNA hybridization with a detection limit of 0.08 fmol L⁻¹. Moreover, the biosensor was applied for the detection of pathogenic bacterium such as DNA from Mycobacterium tuberculosis strand. Developed biosensor has been able to detect a single nucleotide polymorphism (SNP)T (TCG/ TTG) which confers resistance of M. tuberculosis to rifampicin drug.

已经研究了基于新型纳米复合材料（Fc-ac-OMPA / MWCNTs）的直接DNA传感器。该纳米复合材料是通过氧化还原低聚物“寡甲氧基-苯基-乙腈”（Fc-ac-OMPA）和MWCNT通过简单的π-π堆叠相互作用结合而形成的，目的是改善生物传感器的性能。氧化还原指示剂和氧化还原低聚物的官能团已用于监测丙型肝炎DNA探针的电化学行为和直接共价连接的灵活性。该纳米复合材料表现出高性能的DNA杂交，检测极限为0.08fmol L ^-1。此外，该生物传感器被用于检测诸如结核分枝杆菌的DNA的致病细菌。股。研发的生物传感器已经能够检测到赋予结核分枝杆菌对利福平药物耐药性的单核苷酸多态性（SNP）T（TCG / TTG）。