Using stereoretention for the synthesis of E-macrocycles with ruthenium-based olefin metathesis catalysts†,Chemical Science

当前位置： X-MOL 学术 › Chem. Sci. › 论文详情

Our official English website, www.x-mol.net, welcomes your feedback! (Note: you will need to create a separate account there.)

Using stereoretention for the synthesis of E-macrocycles with ruthenium-based olefin metathesis catalysts†
Chemical Science ( IF 7.6 ) Pub Date : 2018-03-14 00:00:00 , DOI: 10.1039/c8sc00435h
Tonia S. Ahmed _{1,

2,

3,

4,

5} , T. Patrick Montgomery _{1,

2,

3,

4,

5} , Robert H. Grubbs _{1,

2,

3,

4,

5}

Affiliation

The synthesis of E-macrocycles is achieved using stereoretentive, Ru-based olefin metathesis catalysts supported by dithiolate ligands. Kinetic studies elucidate marked differences in activity among the catalysts tested, with catalyst 4 providing meaningful yields of products in much shorter reaction times than stereoretentive catalysts 2 and 3. Macrocycles were generated with excellent selectivity (>99% E) and in moderate to high yields (47–80% yield) from diene starting materials bearing two E-configured olefins. A variety of rings were constructed, ranging from 12- to 18-membered macrocycles, including the antibiotic recifeiolide.

中文翻译：

使用立构保留与钌基烯烃复分解催化剂合成E-大环†

E-大环的合成是使用二硫醇盐配体负载的立体保持性，Ru基烯烃复分解催化剂来实现的。动力学研究阐明了所测试的催化剂之间活性的显着差异，其中催化剂4在比立体保持催化剂2和3短得多的反应时间内提供了有意义的产物收率。大环以优异的选择性（> 99％E）和中等至高收率（47-80％收率）从带有两种E-构型烯烃的二烯原料中生成。构建了各种环，范围从12到18元的大环化合物，包括抗生素回收苯环内酯。

更新日期：2018-03-14

点击分享查看原文

点击收藏

公开下载

阅读更多本刊最新论文本刊介绍/投稿指南11