Silver‐Catalyzed Isocyanide Insertion into N−H Bond of Ammonia: [5+1] Annulation to Quinazoline Derivatives,Advanced Synthesis & Catalysis

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Silver‐Catalyzed Isocyanide Insertion into N−H Bond of Ammonia: [5+1] Annulation to Quinazoline Derivatives
Advanced Synthesis & Catalysis ( IF 4.4 ) Pub Date : 2018-03-30 , DOI: 10.1002/adsc.201701623
Lingjuan Zhang ₁ , Juanjuan Li ₁ , Zhongyan Hu ₂ , Jinhuan Dong ₂ , Xian-Ming Zhang ₁ , Xianxiu Xu ₂

Affiliation

A silver‐catalyzed [5+1] annulation of o‐acylaryl isocyanides with ammonium acetate and hydroxlamine was developed for the efficient and practical synthesis of quinazolines and quinazoline 3‐oxides in good to excellent yields, respectively. The domino process involved an unprecedented isocyanide insertion into the N−H bond of ammonia or hydroxylamine and followed by condensation reaction at ambient conditions.

中文翻译：

银催化的异氰酸酯插入氨的NH键中：[5 + 1]与喹唑啉衍生物的环化

开发了一种银催化的邻-酰基芳基异氰化物与乙酸铵和羟胺的[5 + 1]环合反应，可分别以良好或优异的产率高效，实用地合成喹唑啉和喹唑啉3-氧化物。多米诺骨牌过程涉及到前所未有的异氰酸酯插入氨或羟胺的NH键中，然后在环境条件下发生缩合反应。

更新日期：2018-03-30

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