Assuring compliance of intermediate and final quality attributes in a continuous pharmaceutical manufacturing campaign is of utmost importance. Application of corrective actions might be required in real‐time. This work exemplifies the steps needed to identify a linear pulse transfer function for the dynamic behavior of the granule liquid‐to‐solid ratio (%w/w) at the end of the granulation unit of a commercial ConsiGma^TM‐25 production line. Near‐infrared spectroscopy was used to monitor the granule composition in‐line. The outcome for both the tracking and regulator problem using either conventional or model predictive control was implemented and evaluated. Dynamic setpoints were correctly followed and an RMSE of 0.25%w/w with respect to the setpoint was obtained when inducing artificial disturbances. Important practical challenges were also tackled. Examples are fouling, computational limitations, and the limited flexibility of the automation software. Applying the proposed advanced process control solution offers an answer to upstream material flow rate deviations. © 2018 American Institute of Chemical Engineers AIChE J, 64: 2500–2514, 2018

中文翻译：

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液固比控制作为连续双螺杆湿法制粒的高级过程控制解决方案

确保在连续的制药生产活动中达到中级和最终质量属性至关重要。可能需要实时应用纠正措施。这项工作举例说明了为商用ConsiGma ^TM制粒单元末端的颗粒液固比（％w / w）的动态行为识别线性脉冲传递函数所需的步骤。‐25生产线。近红外光谱用于在线监测颗粒组成。实施和评估了使用常规或模型预测控制的跟踪和调节器问题的结果。正确地遵循了动态设定值，并且在引起人为干扰时获得了相对于设定值为0.25％w / w的RMSE。还解决了重要的实际挑战。例如结垢，计算限制以及自动化软件的灵活性有限。应用建议的高级过程控制解决方案可为上游物料流量偏差提供答案。©2018美国化学工程师学会AIChE J，64：2500–2514，2018