Nanodisc‐Targeted STD NMR Spectroscopy Reveals Atomic Details of Ligand Binding to Lipid Environments,ChemBioChem

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Nanodisc‐Targeted STD NMR Spectroscopy Reveals Atomic Details of Ligand Binding to Lipid Environments
ChemBioChem ( IF 2.6 ) Pub Date : 2018-04-26 , DOI: 10.1002/cbic.201800078
Juan C. Muñoz-García ₁ , Rosana Inacio dos Reis ₁ , Richard J. Taylor ₂ , Alistair J. Henry ₂ , Anthony Watts ₁

Affiliation

How do ligands communicate with lipids? Nanodiscs are ideal nanoplatforms for STD NMR assessment of molecular recognition between small molecules and lipids. It was found that the neurotransmitter dopamine can only establish communication with negatively charged lipid environments. MSP: membrane scaffold protein, POPG: hexadecano‐1‐yl‐2‐(9Z‐octadecenoyl)‐sn‐glycero‐3‐phospho‐(1′‐rac‐glycerol).

中文翻译：

纳米盘靶向STD NMR光谱揭示了配体与脂质环境结合的原子细节

配体如何与脂质沟通？纳米圆盘是用于小分子与脂质之间的分子识别的STD NMR评估的理想纳米平台。发现神经递质多巴胺只能与带负电的脂质环境建立联系。MSP：膜支架蛋白，POPG：十六烷-1-基-2-（9 Z-十八烯酰基）-sn-甘油-3-磷酸-（1'- rac-甘油）。

更新日期：2018-04-26

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