An RNA‐Cleaving Catalytic DNA Accelerated by Freezing,ChemBioChem

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An RNA‐Cleaving Catalytic DNA Accelerated by Freezing
ChemBioChem ( IF 2.6 ) Pub Date : 2018-04-26 , DOI: 10.1002/cbic.201800049
Tianmeng Yu ₁ , Wenhu Zhou _{1,

2} , Juewen Liu ₁

Affiliation

Faster when frozen: The EtNa DNAzyme is active for RNA cleavage under different conditions. Surprisingly, freezing accelerated its cleavage activity in the presence of Na⁺, but inhibited it in the presence of Ca²⁺; this is in contrast to most other DNAzymes, which were inhibited by freezing.