2D nanomaterials have attracted considerable research interest in drug delivery systems, owing to their intriguing quantum size and surface effect. Herein, Gd³⁺‐doped monolayered‐double‐hydroxide (MLDH) nanosheets are prepared via a facile bottom‐up synthesis method, with a precisely controlled composition and uniform morphology. MLDH nanosheets as drug carrier are demonstrated in coloading of doxorubicin and indocyanine green (DOX&ICG), with an ultrahigh drug loading content (LC) of 797.36% and an encapsulation efficiency (EE) of 99.67%. This is, as far as it is known, the highest LC level at nearly 100% of EE among previously reported 2D drug delivery systems so far. Interestingly, the as‐prepared DOX&ICG/MLDH composite material shows both pH‐controlled and near‐infrared‐irradiation‐induced DOX release, which holds a promise in stimulated drug release. An in vivo dual‐mode imaging, including near‐infrared fluorescence and magnetic resonance imaging, enables a noninvasive visualization of distribution profiles at the tumor site. In addition, in vitro and in vivo therapeutic evaluations demonstrate an excellent trimode synergetic anticancer activity and superior biocompatibility of DOX&ICG/MLDH. Therefore, MLDH nanosheets provide new perspectives in the design of multifunctional nanomedicine, which shows promising applications in controlled drug delivery and cancer theranostics.

中文翻译：

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单层纳米片具有极高的药物负荷，可以控制分娩和癌症治疗学

2D纳米材料因其引人入胜的量子尺寸和表面效应而在药物输送系统中引起了相当大的研究兴趣。此处，Gd ³⁺掺杂的单层双氢氧化物（MLDH）纳米片是通过一种简便的自下而上合成方法制备的，具有精确控制的成分和均匀的形态。MLDH纳米片作为药物载体在阿霉素和吲哚菁绿（DOX＆ICG）的共载中得到证明，其超高载药量（LC）为797.36％，封装效率（EE）为99.67％。就目前所知，这是迄今为止先前报道的二维药物输送系统中最高的LC水平，接近EE的100％。有趣的是，所制备的DOX＆ICG / MLDH复合材料显示出pH控制和近红外辐射诱导的DOX释放，这有望促进药物释放。体内双模式成像，包括近红外荧光和磁共振成像，实现了肿瘤部位分布图的非侵入性可视化。此外，体外和体内治疗评估表明，DOX＆ICG / MLDH具有出色的三模协同抗癌活性和优异的生物相容性。因此，MLDH纳米片为多功能纳米药物的设计提供了新的视角，显示了在受控药物递送和癌症治疗学中的有希望的应用。