Synthesis, Self-Assembly, and Biomedical Applications of Antimicrobial Peptide–Polymer Conjugates,Biomacromolecules

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Synthesis, Self-Assembly, and Biomedical Applications of Antimicrobial Peptide–Polymer Conjugates
Biomacromolecules ( IF 5.5 ) Pub Date : 2018-03-14 00:00:00 , DOI: 10.1021/acs.biomac.8b00208
Hui Sun ₁ , Yuanxiu Hong ₁ , Yuejing Xi ₁ , Yijie Zou ₁ , Jingyi Gao ₁ , Jianzhong Du _{1,

2}

Affiliation

Antimicrobial peptides (AMPs) have been attracting much attention due to their excellent antimicrobial efficiency and low rate in driving antimicrobial resistance (AMR), which has been increasing globally to alarming levels. Conjugation of AMPs into functional polymers not only preserves excellent antimicrobial activities but reduces the toxicity and offers more functionalities, which brings new insight toward developing multifunctional biomedical materials such as hydrogels, polymer vesicles, polymer micelles, and so forth. These nanomaterials have been exhibiting excellent antimicrobial activity against a broad spectrum of bacteria including multidrug-resistant (MDR) ones, high selectivity, and low cytotoxicity, suggesting promising potentials in wound dressing, implant coating, antibiofilm, tissue engineering, and so forth. This Perspective seeks to highlight the state-of-the-art strategy for the synthesis, self-assembly, and biomedical applications of AMP–polymer conjugates and explore the promising directions for future research ranging from synthetic strategies, multistage and stimuli-responsive antibacterial activities, antifungi applications, and potentials in elimination of inflammation during medical treatment. It also will provide perspectives on how to stem the remaining challenges and unresolved problems in combating bacteria, including MDR ones.

中文翻译：

抗菌肽-聚合物缀合物的合成，自组装和生物医学应用

抗菌肽（AMPs）由于其出色的抗菌效率和驱动抗菌素耐药性（AMR）的比率较低而受到了广泛的关注，而抗菌素耐药性（AMR）在全球范围内一直上升到令人震惊的水平。将AMPs结合到功能聚合物中，不仅保留了出色的抗微生物活性，而且降低了毒性并提供了更多的功能，这为开发多功能生物医学材料（例如水凝胶，聚合物囊泡，聚合物胶束等）带来了新的见识。这些纳米材料对多种细菌均表现出出色的抗菌活性，包括耐多药（MDR）细菌，高选择性和低细胞毒性，这表明在伤口敷料，植入物涂层，抗生物膜，组织工程等方面潜力巨大。该观点旨在强调AMP-聚合物共轭物的合成，自组装和生物医学应用的最新策略，并探索未来研究的有前途的方向，包括合成策略，多阶段和刺激性抗菌活性，抗真菌剂的应用以及在医疗过程中消除炎症的潜力。它还将提供有关如何抵抗细菌（包括MDR细菌）中尚存的挑战和未解决问题的观点。以及在医疗过程中消除炎症的潜力。它还将提供有关如何抵抗细菌（包括MDR细菌）中尚存的挑战和未解决问题的观点。以及在医疗过程中消除炎症的潜力。它还将提供有关如何抵抗细菌（包括MDR细菌）中尚存的挑战和未解决问题的观点。

更新日期：2018-03-14

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