The oxidative SS coupling of thiol to disulfide is an imperative chemical transformation in the domain of biological processes and also finds numerous chemical applications. The CeO₂ and ZnO are significant catalysts for oxidation of thiol to disulfide and N-acetylation of amines respectively. Dithiobis(phenylene)bis(benzyldeneimine) moiety containing N-acetyl and disulfide functional groups is a potential antimicrobial agent with Leishmanicidal and antihyperlipidemic activities. Herein, we report a synchronized catalytic application of Ce doped ZnO (Ce-ZnO) and CeO₂-Ce-ZnO composites for selective synthesis of Dithiobis(phenylene)bis(benzyldeneimine) from o-amino thiol. The Ce-ZnO samples were synthesized by simple co precipitation method by calcination of hydroxide precursors at 400 °C to get 0–10% Ce-ZnO nanocrystallites. The formation of CeO₂-Ce-ZnO composite material was observed beyond 1.5% Ce concentration. The synthesized materials were well characterized by IR, XRD, DRS spectroscopy and SEM-EDS analysis. The application of Ce doped ZnO as an efficient catalyst towards the selective N-acetylation and concurrent S-oxidation of o-amino thiol to afford Dithiobis(phenylene)bis(benzyldeneimine) at ambient temperature in acetonitrile was deliberated. Among all screened catalysts, the maximum selectivity was found for 7.5% Ce-ZnO as CeO₂-Ce-ZnO composite catalyst. Lewis acidic property of catalyst supported probable mechanism for achieved dual transformations. Also, the 7.5% Ce-ZnO catalyst has demonstrated a versatile SS coupling ability for variety of thiol substrates with excellent stability.

硫醇与二硫键的氧化S S偶联是生物过程领域中必不可少的化学转化，并且也发现了许多化学应用。CeO ₂和ZnO分别是硫醇氧化为二硫化物和胺的N-乙酰化的重要催化剂。含有N-乙酰基和二硫键官能团的二硫代双（亚苯基）双（苄基亚胺）部分是一种潜在的具有杀菌作用和降血脂活性的抗菌剂。本文中，我们报道了Ce掺杂的ZnO（Ce-ZnO）和CeO ₂ -Ce-ZnO复合材料的同步催化应用，用于从邻位选择性合成二硫代双（亚苯基）双（苄基亚胺）-氨基硫醇。通过简单的共沉淀法，在400°C下煅烧氢氧化物前体，合成Ce-ZnO样品，得到0-10％的Ce-ZnO纳米微晶。超过1.5％的Ce浓度观察到CeO ₂ -Ce-ZnO复合材料的形成。通过IR，XRD，DRS光谱和SEM-EDS分析对合成的材料进行了很好的表征。研究了Ce掺杂的ZnO作为有效催化剂对邻氨基硫醇的选择性N-乙酰化和同时S-氧化的反应，从而在环境温度下在乙腈中提供二硫代双（亚苯基）双（苄基亚胺）。在所有筛选的催化剂中，发现7.5％的Ce-ZnO作为CeO ₂的最大选择性-Ce-ZnO复合催化剂。催化剂的路易斯酸性质支持了实现双重转化的可能机理。同样，7.5％的Ce-ZnO催化剂对多种硫醇底物表现出广泛的S S偶联能力，并具有出色的稳定性。