Step-Growth Cyclo-Oligomerization for the Preparation of Di- and Tetrafunctionalized Pillar[5]arenes,The Journal of Organic Chemistry

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Step-Growth Cyclo-Oligomerization for the Preparation of Di- and Tetrafunctionalized Pillar[5]arenes
The Journal of Organic Chemistry ( IF 3.3 ) Pub Date : 2018-03-14 00:00:00 , DOI: 10.1021/acs.joc.8b00073
Weipeng Mao ₁ , Shuaijun Zhan ₁ , Bowei Zhu ₁ , Da Ma ₁

Affiliation

The preparation of complex functionalized pillar[n]arenes (PA[n]s) is challenging by one-pot cocyclization or selective deprotection method. We developed a step-growth cyclo-oligomerization method to synthesize functionalized PA[5]s. Dimers, trimers, and tetramers were synthesized and characterized. With this new method, we were able to prepare three di- and tetrafunctionalized PA[5]s. By using a multistep synthetic strategy, the chance to form constitutional isomers and other by-products was reduced. Therefore, complex tetrafunctionalized PA[5]s were prepared with improved yield.

中文翻译：

分步增长环-低聚反应制备双官能和四官能的立柱[5]芳烃

一锅共环化或选择性脱保护方法对制备复杂的功能化支柱[ n ]芳烃（PA [ n ] s）具有挑战性。我们开发了一种逐步增长的环状低聚方法来合成功能化的PA [5]。合成并表征了二聚体，三聚体和四聚体。通过这种新方法，我们能够制备出三个双功能和四功能的PA [5]。通过使用多步合成策略，减少了形成结构异构体和其他副产物的机会。因此，以提高的产率制备了复杂的四官能的PA [5]。

更新日期：2018-03-14

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