Composite-dissolving microneedle patches for chemotherapy and photothermal therapy in superficial tumor treatment,Biomaterials Science

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Composite-dissolving microneedle patches for chemotherapy and photothermal therapy in superficial tumor treatment
Biomaterials Science ( IF 5.8 ) Pub Date : 2018-03-14 00:00:00 , DOI: 10.1039/c8bm00005k
Peng Pei _{1,

2,

3,

4} , Fan Yang _{4,

5,

6,

7,

8} , Jiaxing Liu _{1,

2,

3,

4} , Haoran Hu _{4,

5,

6,

7,

8} , Xiaoyu Du _{1,

2,

3,

4} , Nobutaka Hanagata _{9,

10,

11,

12} , Shichang Zhao _{4,

5,

6,

7,

8} , Yufang Zhu _{1,

2,

3,

4}

Affiliation

A combination of chemotherapy and photothermal therapy (PTT) has emerged as a promising strategy for cancer therapy. To ensure that the chemotherapeutic drug and photothermal agent can be simultaneously delivered to the tumor site to exert their synergistic effects, a safe and efficient delivery system is needed. Herein, we fabricated doxorubicin hydrochloride (DOX)- and indocyanine green (ICG)-loaded microneedle (MN) patches (PVP@DOX/MSN@ICG) using a two-step casting process. Mesoporous silica nanoparticles (MSNs) were used to improve the ICG stability and avoid reducing its PTT efficiency in vivo. The MN patches exhibited a good skin penetration ability, and the tips of the MN patches were dissolved by the interstitial fluid to release DOX and ICG at the tumor sites. Under 808 nm laser irradiation within 2 min, the local temperature in the tumor quickly reached 48 °C at a low power of 0.34 W cm⁻². A combination of chemotherapy and PTT for PVP@DOX/MSN@ICG MN patches may maximally induce human osteosarcoma MG-63 cells in vitro. Moreover, the in vivo results showed that PVP@DOX/MSN@ICG MN patches had the best antitumor effects because of synergistic chemotherapy and PTT. Therefore, the composite-dissolving MN patch is a promising strategy for enhancing the antitumor effect of chemotherapy alone and shows the potential for the synergistic therapy of superficial tumors.

中文翻译：

用于化学疗法和光热疗法的复合溶解微针贴剂在浅表肿瘤治疗中的应用

化学疗法和光热疗法（PTT）的结合已成为一种有前途的癌症治疗策略。为了确保化学治疗药物和光热剂可以同时递送至肿瘤部位以发挥其协同作用，需要安全有效的递送系统。在这里，我们使用两步铸造工艺制造了盐酸阿霉素和吲哚菁绿（ICG）加载的微针（MN）贴片（PVP @ DOX / MSN @ ICG）。使用介孔二氧化硅纳米粒子（MSN）改善ICG稳定性并避免降低其体内PTT效率。MN斑块表现出良好的皮肤渗透能力，并且MN斑块的尖端被间质液溶解以在肿瘤部位释放DOX和ICG。在2分钟内的808 nm激光照射下，肿瘤的局部温度以0.34 W cm ^-2的低功率迅速达到48°C 。PVP @ DOX / MSN @ ICG MN斑块的化学疗法和PTT疗法的结合可以在体外最大程度地诱导人骨肉瘤MG-63细胞。而且，体内结果表明，PVP @ DOX / MSN @ ICG MN贴剂具有协同化疗和PTT的最佳抗肿瘤作用。因此，可溶解复合物的MN贴片是增强单独化疗抗肿瘤作用的一种有前途的策略，并显示出协同治疗浅表肿瘤的潜力。

更新日期：2018-03-14

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