Despite the widespread use of synthetic meshes in the surgical treatment of the hernia pathology, the election criteria of a suitable mesh for specific patient continues to be uncertain. Thus, in this work, we propose a methodology to determine in advance potential disadvantages on the use of certain meshes based on the patient-specific abdominal geometry and the mechanical features of the certain meshes.

To that purpose, we have first characterized the mechanical behavior of four synthetic meshes through biaxial tests. Secondly, two of these meshes were implanted in several New Zealand rabbits with a total defect previously created on the center of the abdominal wall. After the surgical procedure, specimen were subjected to in vivo pneumoperitoneum tests to determine the immediate post-surgical response of those meshes after implanted in a healthy specimen. Experimental performance was recorded by a stereo rig with the aim of obtaining quantitative information about the pressure-displacement relation of the abdominal wall. Finally, following the procedure presented in prior works (Simón-Allué et al., 2015, Simón-Allué et al., 2017), a finite element model was reconstructed from the experimental measurements and tests were computationally reproduced for the healthy and herniated cases. Simulations were compared and validated with the in vivo behavior and results were given along the abdominal wall in terms of displacements, stresses and strain.

Mechanical characterization of the meshes revealed Surgipro ${}^{\mathit{TM}}$ as the most rigid implant and Neomesh SuperSoft® as the softer, while other two meshes (Neomesh Soft®, Neopore®) remained in between. These two meshes were employed in the experimental study and resulted in similar effect in the abdominal wall cavity and both were close to the healthy case. Simulations confirmed this result while showed potential objections in the case of the other two meshes, due to high values in stresses or elongation that may led to discomfort in real tissue. The use of this methodology on human surgery may provide the surgeons with reliable and useful information to avoid certain meshes on specific-patient treatment.

尽管在疝病理的外科手术治疗中广泛使用合成网片，但是对于特定患者的合适网片的选择标准仍然不确定。因此，在这项工作中，我们提出了一种基于患者特定的腹部几何形状和某些网格的机械特征，预先确定使用某些网格的潜在缺点的方法。

为此，我们首先通过双轴测试表征了四个合成网格的机械性能。其次，将其中两个网布植入数只新西兰兔体内，这些兔以前在腹壁中心处形成了总缺损。手术后，对标本进行体内处理进行气腹测试，以确定将这些网片植入健康标本后的即时手术后反应。为了获得有关腹壁压力-位移关系的定量信息，用立体声钻机记录了实验性能。最后，按照先前工作中介绍的程序（Simón-Allué等人，2015;Simón-Allué等人，2017），从实验测量结果中重建有限元模型，并对健康和突出的病例进行计算重现测试。对模拟进行了比较并通过体内行为进行了验证，并根据位移，应力和应变沿腹壁给出了结果。

网格的机械表征揭示了Surgipro ${}^{\mathit{TM值}}$作为最坚硬的植入物，使用Neomesh SuperSoft®作为较软的植入物，而其他两个网孔（Neomesh Soft®，Neopore®）则留在两者之间。这两个网被用于实验研究中，并在腹壁腔中产生相似的效果，并且都接近健康病例。模拟结果证实了这一结果，但在其他两个网格中却显示出潜在的反对意见，这是由于应力或伸长率的高值可能导致真实组织的不适感。在人体外科手术中使用这种方法可以为外科医生提供可靠和有用的信息，从而避免针对特定患者的治疗产生某些障碍。