Chinese jujube is commonly used in folklore medicine. This study aimed to examine the in vivo immunomodulatory activity of two acidic polysaccharides, HP1 and HP2, extracted and purified from Zizyphus jujuba cv. Huizao (which remains extensively unexplored). HP1 and HP2 had the same monosaccharide species and manganese contents, but differed in their molar rhamnose, arabinose, mannose, glucose, galactose and uronic acid contents (7.32 and 35.9%, as galacturonic acid), Mw (68.7 and 111 kDa, respectively), and contents of K, Cr, Cu, Zn, Pb and Ca. Both HP1 and HP2 could significantly (P < 0.05) increase spleen and thymus indices, promote serum hemolysin formation, enhance the phagocytic activity of macrophages and inhibit footpad edema of mice, with HP2 likely being a more consistent and potent immunomodulator. This study clearly demonstrates the potential of Z. jujuba cv. Huizao polysaccharides as immunomodulators and their associated chemical characteristics and working mechanisms.

大枣在民俗医学中很常用。这项研究旨在检查从酸枣（Zyzyphus jujuba cv）提取和纯化的两种酸性多糖HP1和HP2的体内免疫调节活性。灰枣（至今尚未开发）。HP1和HP2具有相同的单糖种类和锰含量，但摩尔摩尔数的鼠李糖，阿拉伯糖，甘露糖，葡萄糖，半乳糖和糖醛酸含量（分别为半乳糖醛酸的7.32和35.9％），Mw（分别为68.7和111 kDa） ，以及K，Cr，Cu，Zn，Pb和Ca的含量。HP1和HP2均可能显着（P <0.05）增加脾脏和胸腺指数，促进血清溶血素形成，增强巨噬细胞的吞噬活性并抑制小鼠足垫水肿，HP2可能是更一致和有效的免疫调节剂。这项研究清楚地证明了枣树的潜力。灰枣多糖作为免疫调节剂及其相关的化学特性和工作机理。