In metazoans, thousands of intracellular proteins are modified with O-linked β-N-acetylglucosamine (O-GlcNAc) in response to a wide range of stimuli and stresses. In particular, a complex and evolutionarily conserved interplay between O-GlcNAcylation and oxidative stress has emerged in recent years. Here, we review the current literature on the connections between O-GlcNAc and oxidative stress, with a particular emphasis on major signaling pathways, such as KEAP1/NRF2, FOXO, NFκB, p53 and cell metabolism. Taken together, this work sheds important light on the signaling functions of protein glycosylation and the mechanisms of stress responses alike and illuminates how the two are integrated in animal cell physiology.

中文翻译：

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氧化应激和 O-GlcNAc 信号通路之间的功能串扰。


在后生动物中，数以千计的细胞内蛋白质被 O-连接 β-N-乙酰氨基葡萄糖 (O-GlcNAc) 修饰，以响应各种刺激和应激。特别是，近年来出现了 O-GlcNAc 化和氧化应激之间复杂且进化上保守的相互作用。在此，我们回顾了有关 O-GlcNAc 与氧化应激之间关系的最新文献，特别强调主要信号通路，如 KEAP1/NRF2、FOXO、NFκB、p53 和细胞代谢。总而言之，这项工作为蛋白质糖基化的信号传导功能和应激反应的机制提供了重要的线索，并阐明了两者如何在动物细胞生理学中整合。