By means of a systematic approach, several green solvent candidates were tested for their feasibility to replace the reprotoxic dimethylformamide (DMF) as a solvent used in solid-phase peptide synthesis (SPPS). According to the results presented in this paper, it is clear that N-butylpyrrolidinone (NBP) is the best green solvent candidate to replace DMF in SPPS.

中文翻译：

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N-丁基吡咯烷酮作为固相肽合成的替代溶剂

通过系统的方法，测试了几种绿色溶剂候选物替代前毒性二甲基甲酰胺（DMF）作为固相肽合成（SPPS）中使用的溶剂的可行性。根据本文提供的结果，很明显，N-丁基吡咯烷酮（NBP）是替代SPPS中DMF的最佳绿色溶剂。